| Study programme competencies |
| Code | Study programme competences |
| A1 | Ability to use chemistry terminology, nomenclature, conventions and units |
| A5 | Understanding of principles of thermodynamics and its applications in chemistry |
| A9 | Knowledge of structural characteristics of chemical and stereochemical compounds, and basic methods of structural analysis and research |
| A10 | Knowledge of chemical kinetics, catalysis and reaction mechanisms |
| A12 | Ability to relate macroscopic properties of matter to its microscopic structure |
| A13 | Understanding of chemistry of main biological processes |
| A14 | Ability to demonstrate knowledge and understanding of concepts, principles and theories in chemistry |
| A15 | Ability to recognise and analyse new problems and develop solution strategies |
| A16 | Ability to source, assess and apply technical bibliographical information and data relating to chemistry |
| A21 | Understanding of qualitative and quantitative aspects of chemical problems |
| A24 | Ability to explain chemical processes and phenomena clearly and simply |
| A25 | Ability to recognise and analyse link between chemistry and other disciplines, and presence of chemical processes in everyday life |
| A28 | Acquisition, assessment and application of basic principles of industrial activity, organisation and task management |
| B1 | Learning to learn |
| B2 | Effective problem solving |
| B3 | Application of logical, critical, creative thinking |
| B4 | Working independently on own initiative |
| B6 | Ethical, responsible, civic-minded professionalism |
| B7 | Effective workplace communication |
| C1 | Ability to express oneself accurately in the official languages of Galicia (oral and in written) |
| C3 | Ability to use basic information and communications technology (ICT) tools for professional purposes and learning throughout life |
| C4 | Self-development as an open, educated, critical, engaged, democratic, socially responsible citizen, equipped to analyse reality, diagnose problems, and formulate and implement informed solutions for the common good |
| C5 | Understanding importance of entrepreneurship, and knowledge of resources available for people with business ideas |
| C6 | Ability to assess critically the knowledge, technology and information available for problem solving |
| C7 | Acceptance as a professional and as a citizen of importance of lifelong learning |
| C8 | Understanding role of research, innovation and technology in socio-economic and cultural development |
| Learning aims | |||
| Subject competencies (Learning outcomes) | Study programme competences | ||
| Know the structure and mode of action of drugs and the relationship with biological activity | A1 A5 A9 A13 A14 A15 A16 A21 A24 A25 A28 |
B1 B2 B3 B4 B6 B7 |
C1 C3 C4 C5 C6 C7 C8 |
| Know the impact of drugs and the pharmaceutical companies in the society. | A12 A13 A14 A16 A24 A25 A28 |
B1 B3 B4 B6 B7 |
C1 C3 C4 C6 C7 C8 |
| Know basic principles and strategies used to design and synthesized drugs. | A1 A9 A10 A13 A14 A15 A16 A21 A24 A25 A28 |
B1 B2 B3 B4 B6 B7 |
C1 C3 C4 C5 C6 C7 C8 |
| Contents |
| Topic | Sub-topic |
| Chapter 1. Introduction to Medicinal Chemistry | Introduction to Medicinal Chemistry: definition and basic concepts. Drugs: nomenclature and classification |
| Chapter 2. Molecular recognition: interaction between drugs and targets | Interactions between drugs and targets: lipids, carbohydrates, proteins (enzimes, membrane receptors), nucleis acids. Types of interactions, molecular topology and biological activity. |
| Chapter 3. Phramacokinetics and physicochemical properties of drugs | Absortion, Distribution, Metabolism and Excretion processes. Drug delivery: The biological membrane. |
| Chapter 4. Drug metabolism | Absortion, Distribution, Metabolism and Excretion processes. Drug delivery: The biological membrane. |
| Chapter 5. Drug discovery | Main sources and ways for drug discovery. Structure-activity relationship. Clinic phases. |
| Chapter 6. Drug design | Main feutures optimizing the activity of drugs: interaction, metabolism studies. |
| Chapter 7. Drug synthesis | Main synthetis methods for the synthesis of drugs |
| Planning | |||
| Methodologies / tests | Ordinary class hours | Student’s personal work hours | Total hours |
| Introductory activities | 1 | 0 | 1 |
| Guest lecture / keynote speech | 18 | 36 | 54 |
| Seminar | 7 | 21 | 28 |
| Field trip | 10 | 5 | 15 |
| Oral presentation | 2 | 8 | 10 |
| Mixed objective/subjective test | 3.5 | 0 | 3.5 |
| Personalized attention | 1 | 0 | 1 |
| (*)The information in the planning table is for guidance only and does not take into account the heterogeneity of the students. | |||
| Methodologies |
| Methodologies | Description |
| Introductory activities | In this initial session the contents, methodology and evaluation of the subject will be presented |
| Guest lecture / keynote speech | The contents will be introducted through keynote speeches. In order to facilitate their monitoring, students will be provide with copies of the presentations sent by the Moodle platform. |
| Seminar | The contents of each chapter will be discussed in seminars by solving exercises and analysis of practical cases. Students will have early enough problem sets through the Moodle platform. We may request delivery of solved exercises. |
| Field trip | As a practical activity visits to research centers and/or related companies with Medicinal Chemistry aims will be scheduled. Attendance at these activities is mandatory and the development of an individual activity report will be necessary |
| Oral presentation | At the end of the subject students will perform an oral presentation related to a case study where the contents of the material are applied. |
| Mixed objective/subjective test | A test with questions related to the contents of the subject will be asked. |
| Personalized attention |
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| Assessment | ||
| Methodologies | Description | Qualification |
| Seminar | The active participation of students in solving the problems of the bulletins and assignment submitted will be assessed. Competencies: A1, A2, A9, A10, A12-16, A21, A24, A27-28, B2-4, B7, C2 |
20 |
| Field trip | Attendance and the final report will be assessed. Competencies: A28, B6, C5, C6, C7, C8 |
10 |
| Oral presentation | The quality of the exposition in terms of presentation, organization, content, defense and discussion of results will be assessed. Competencies: A1, A5, A12-16, A24-25, B4, B7, C2, C3, C6 |
20 |
| Mixed objective/subjective test | The responses in the written exam will be evaluated. Skills: A1, A5, A10, A12, A13, A14, A24, B2, B3, |
50 |
| Assessment comments | ||
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To qualify an student as "not presented" it will be necessary to perform activities computing less than 50% in the evaluation. According to current regulations, the student will have two chances, the first in June and the second in July. Students who fail the course at the earliest opportunity retained the grade earned in the seminar work, field trip and oral presentation, and made a second mixed objective/subjective test on dates determined in the timetable set by the Faculty Boardtest. Students are assessed at the second opportunity may only be eligible for honors if they have not been covered at the first opportunity. The teaching-learning process, including assessment, refers to an academic course and therefore start again with a new academic year, including all activities and evaluation procedures that are scheduled for that course. |
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| Sources of information |
| Basic |
Patrick, G. L (2013). An Introduction to Medicinal Chemistry. New York: Oxford University Press
Avendaño, C (2001). Introducción a la Química Farmacéutica. Madrid: McGraw-Hill
Delgado, A.; Minguillón, C.; Joglar, J. (2003). Introducción a la Química Terapéutica. Madrid: Díaz de Santos
Delgado, A.; Minguillón, C.; Joglar, J. (2002). Introducción a la síntesis de fármacos. Madrid: Síntesis
Thomas, Gareth (2007). Medicinal Chemistry: An introduction. Wiley
E. J. Corey; B. Czakó; L. Kürti (2007). Molecules and Medicines. Wiley
Galbis Perez, J. A (2004). Panorama actual de la Química Farmacéutica. Sevilla: Universidad de Sevilla |
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| Recommendations | ||||
| Subjects that it is recommended to have taken before |
| Subjects that are recommended to be taken simultaneously | |
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| Subjects that continue the syllabus | ||||
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| Other comments | |