Teaching GuideTerm Faculty of Science |
Grao en Química |
Subjects |
Medicinal Chemistry |
Contents |
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Identifying Data | 2018/19 | |||||||||||||
Subject | Medicinal Chemistry | Code | 610G01040 | |||||||||||
Study programme |
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Descriptors | Cycle | Period | Year | Type | Credits | |||||||||
Graduate | 2nd four-month period |
Fourth | Optional | 4.5 | ||||||||||
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Topic | Sub-topic |
Chapter 1. Basic principles in Medicinal Chemistry | 1.1 Medicinal Chemistry : definition and basic concepts 1.2 Historical Perspective . 1.3 Pharmacokinetics and Pharmacodynamics Drug Discovery 1.4 1.5 Drugs: nomenclature and classification |
Chapter 2. Molecular basis on pharmacological activity: Pharmacodynamics |
2.1 Drug-receptor interactions . Molecular topology and biological activity 2.2 Proteins: structure and function. Protein Interactions 2.3 Enzymes: enzymatic catalysis. Michaelis - Menten equation . Enzyme inhibition : Types 2.5 Cell receptors: structure and classification . 2.6 Nucleic Acids . Structure and functions. Drug interactions with nucleic acids 2.7 Interactions with lipid and carbohydrate |
Chapter 3. Phramacokinetics | 3.1 ADME processes. 3.2 Absorption of drugs. Modes of administration . Physicochemical properties of drugs : Lipinsky rules . Bioavailability . 3.3 Distribution of drugs. Blood : composition and properties. Removal rate . Mid life. Volume of distribution 3.4 Drug metabolism : metabolism in phase I and phase II 3.5 Elimination of drugs. |
Chapter 5. Drug discovery | 4.1 Steps in drug discovery. Biological target vs Phenotypic approach. Structural diversity. Chemical space. Drug binding energy. High Throughput Screening ( HTS ). Chemical libraries: combinatorial chemistry , parallel synthesis , solid phase synthesis 4.2 Strategies in drug discovery (lead discovery) . Screening modes . Drug screening methods . Drug Design 4.3 Optimization of drugs (lead optimization) . Structure- actividadIdentificación pharmacophore . Pharmacomodulation : modification of functional groups. Optimization receptor binding and pharmacokinetics . |
Chapter 7. Drug synthesis | Main synthetis methods for the synthesis of drugs |
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