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Teaching GuideTerm Faculty of Science |
| Máster Universitario en Bioloxía Molecular, Celular e Xenética (semipresencial) |
 Subjects |
| Genetic Variation Mechanisms |
| Contents |
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| Identifying Data | 2023/24 | |||||||||||||
| Subject | Genetic Variation Mechanisms | Code | 610441005s | |||||||||||
| Study programme |
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| Descriptors | Cycle | Period | Year | Type | Credits | |||||||||
| Official Master's Degree | 1st four-month period |
First | Obligatory | 3 | ||||||||||
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| Topic | Sub-topic |
| Topic 1. Nature of mutations. | Estimates of mutation rate and frequency. Types of lesions caused by mutations. Physical and chemical mutagens. Reversion and deletion. Paramutation. |
| Topic 2. DNA repair mechanisms. | Preventive methods. Direct repair. Excision repair. Post-replication repair. |
| Topic 3. Genetic diseases related to mutagenic agents. | Cancer. Diseases due to failures in repair systems. |
| Topic 4. Mobile DNA: | abundance in genomes. Classifications of transposable elements. Proliferation. Modular evolution. Impact on genomes. Domestication. |
| Topic 5. Recombination processes. | Recombination rates. Gene conversion. Sexual dimorphism of the rate of recombination, crossing over and gene conversion. Biased gene conversion. |
| Topic 6. Evolution of scientific thinking about the origin of genetic variability. The contribution of Woese. | Introduction: Cell evolution: the "bumpy" path to "who knows where" History of evolutionary thought: Lamarck History of evolutionary thought: Darwin History of evolutionary thought: Modern Synthesis of Evolutionary Biology State of Microbiology (and Virology) for most of the 20th century Carl Woese LUCA Generation of genetic variability in the beginning of life |
| Unit 7. Microbial evolution in the era of genomics | Introduction The turbulent dynamics of microbial evolution HGT Damned concepts of classical genetics: genetic elements with Lamarckian flavor? Damned concepts of classical genetics: Evolution of evolution? |
| Unit 8. The mysterious world of viruses | Introduction figures and definitions Are the viruses alive? Early ideas about the evolution of viruses Structural biology allows a deep look into the past The origin of viral replicons When did viruses originate? Gene flow between viruses and hosts New discoveries about the evolution of viruses Viral population dynamics models conclusions |
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