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Teaching GuideTerm Faculty of Science |
| Mestrado Universitario en Ciencias. Tecnoloxías e Xestión Ambiental (plan 2012) |
 Subjects |
| Structural Analysis and Synthetic Planning |
| Contents |
| Identifying Data | 2018/19 | |||||||||||||
| Subject | Structural Analysis and Synthetic Planning | Code | 610500003 | |||||||||||
| Study programme |
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| Descriptors | Cycle | Period | Year | Type | Credits | |||||||||
| Official Master's Degree | 1st four-month period |
First | Optional | 6 | ||||||||||
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| Topic | Sub-topic |
| Unit 1: Mass spectrometry. | Ionization methods: IC, FAB, APCI, ESI and MALDI. Applications for obtaining the molecular formula of a compound. Mass spectrometry of biomolecules: proteins and nucleic acids. Tandem mass spectrometry (MS / MS). |
| Unit 2: Multidimensional NMR technics. | The chemical shift and spin-spin coupling. Relaxation in NMR: NOE, nOediff. The polarization transfer: INEPT, DEPT and APT experiments. Two-dimensional NMR spectroscopy, basic concepts. Experiments COSY, HETCOR, NOESY, ROESY and INADEQUATE. Reverse Spectroscopy: HMQC Vs. HSQC. HMBC. Methods of J-resolved: JHH; JCH. Measurements of long-distance coupling constants, LR-COSY and J-HMBC. More complex experiments: 1H-1H TOCSY (HOHAHA), HSQC-TOCSY, HSQC-NOESY and HETLOC. |
| Unit 3. Structural analysis in Organic Chemistry | Strategies for solving combined problems. |
| Unit 4. Asymmetric synthesis | Introduction. Basic principles. Kinetic resolution. Stereoselective synthesis: chiral auxiliaries. Catalytic processes. |
| Unit 5. Planning and strategies in organic synthesis | Retrosynthetic analysis. Selectivity in organic synthesis. Protecting groups in organic synthesis. |
| Unit 6. Reduction reactions. | Reduction of alkenes: Asymmetric hydrogenation. Hydroboration reactions. Reactions of hydroformylation. Reduction of ketones and imines. Hydrogenation reactions. Reactions with oxazoborolidines. Hydrosilylation reactions. |
| Unit 7. Oxydation reactions. | Epoxydation of alkenes. Epoxydation of allylic alcohols. Epoxydation with salts of manganese (salen). Formation of azidirines. Dihydroxylation of alkenes. Aminohydroxylation of alkenes. Oxidation of Baeyer-Villiger and related |
| Unit 8. Reaction of nucleohylic addition to carbonyl compounds | Addition of organometallic zinc. Addition of cyanide ion. Alkylation of aldehydes. The aldol reaction. Addition reactions to imines. Baylis-Hillman reaction. Conjugate Addition Reactions. |
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