|Grao en Química|
|Advanced Organic Chemistry|
|Subject||Advanced Organic Chemistry||Code||610G01030|
|Graduate||1st four-month period
|Chapter 1. Stereochemistry and conformational analysis||Static and dynamic stereochemistry. Stereoselective and stereospecific chemical reactions (chemo-, regio- and stereoselective/specific reactions).
Conformational analysis: conformational effects on reactivity.
|Chapter 2. Pericyclic reactions||Introduction: characteristics of pericyclic reactions and theoretical approaches. Electrocyclic, Cycloaddition reactions and sigmatropic rearrangements.|
|Chapter 3. Free-Radical reactions||Generation and stability of free radicals. Main free-radical reactions.|
|Chapter 4. Generation of carbon-carbon bond by enols and enolates.||Alkylation, acylation and conjugate addition of enols and enolates|
|Chapter 5. Generation of carbon-carbon bond by organometallic compounds||Organometallic reagents to make carbon-carbon bonds. Reactions involving transition metal complexes.|
|Chapter 6. Generation of carbon- heteroatom bonds||Generation of carbon and oxygen, nitrogen, halide and sulfur bonds.|
|Chapter 7. Functional group interconversion reactions.||Main Functional group interconversion reactions Functional group interconversions through reduction and oxidation reactions.|
|Chapter 8. Protective groups in organic synthesis||The role of protective groups in organic synthesis. The concept of orthogonal sets. Hydroxyl, diols, aldehyde and ketone carbonyl, carboxylic acid and amine protecting groups.|
|Chapter 9. Retrosyntetic analysis.||Synthetic analysis and planning. Retrosyntetic analysis methodology. Types of transformations: disconnections, connections, functional group interconversion, addition and removing functional groups. Economic issues in retrosyntetic analysis. Illustrative synthesis. s|