Teaching GuideTerm
Faculty of Science
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Grao en Química
 Subjects
  Medicinal Chemistry
   Contents
Topic Sub-topic
Chapter 1. Basic principles in Medicinal Chemistry 1.1 Medicinal Chemistry : definition and basic concepts
1.2 Historical Perspective .
1.3 Pharmacokinetics and Pharmacodynamics
1.4 Drug Discovery
1.5 Drugs: nomenclature and classification
Chapter 2. Molecular basis on pharmacological activity:
Pharmacodynamics
2.1 Drug-receptor interactions . Molecular topology and biological activity
2.2 Proteins: structure and function. Protein Interactions
2.3 Enzymes: enzymatic catalysis. Michaelis - Menten equation . Enzyme inhibition : Types
2.5 Cell receptors: structure and classification .
2.6 Nucleic Acids . Structure and functions. Drug interactions with nucleic acids
2.7 Interactions with lipid and carbohydrate
Chapter 3. Phramacokinetics 3.1 ADME processes.
3.2 Absorption of drugs. Modes of administration . Physicochemical properties of drugs : Lipinsky rules . Bioavailability .
3.3 Distribution of drugs. Blood : composition and properties. Removal rate . Mid life. Volume of distribution
3.4 Drug metabolism : metabolism in phase I and phase II
3.5 Elimination of drugs.
Chapter 5. Drug discovery 4.1 Steps in drug discovery. Biological target vs Phenotypic approach. Structural diversity. Chemical space. Drug binding energy. High Throughput Screening ( HTS ). Chemical libraries: combinatorial chemistry , parallel synthesis , solid phase synthesis
4.2 Strategies in drug discovery (lead discovery) . Screening modes . Drug screening methods . Drug Design
4.3 Optimization of drugs (lead optimization) . Structure- actividadIdentificación pharmacophore . Pharmacomodulation : modification of functional groups. Optimization receptor binding and pharmacokinetics .
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