Study programme competencies |
Code
|
Study programme competences / results
|
A1 |
Define concepts, principles, theories and specialized facts of different areas of chemistry. |
A2 |
Suggest alternatives for solving complex chemical problems related to the different areas of chemistry. |
A3 |
Innovate in the methods of synthesis and chemical analysis related to the different areas of chemistry |
A4 |
Apply materials and biomolecules in innovative fields of industry and chemical engineering. |
A9 |
Promote innovation and entrepreneurship in the chemical industry and in research. |
B1 |
Possess knowledge and understanding to provide a basis or opportunity for originality in developing and / or applying ideas, often within a research context |
B2 |
Students should apply their knowledge and ability to solve problems in new or unfamiliar environments within broader (or multidisciplinary) contexts related to their field of study. |
B4 |
Students should be able to communicate their conclusions, and the knowledge and the reasons that support them to specialists and non-specialists in a clear and unambiguous manner |
B5 |
Students must possess learning skills to allow them to continue studying in a way that will have to be largely self-directed or autonomous. |
B7 |
Identify information from scientific literature by using appropriate channels and integrate such information to raise and contextualize a research topic |
B10 |
Use of scientific terminology in English to explain the experimental results in the context of the chemical profession |
B11 |
Apply correctly the new technologies to gather and organize the information to solve problems in the professional activity. |
C1 |
CT1 - Elaborar, escribir e defender publicamente informes de carácter científico e técnico |
C3 |
CT3 - Traballar con autonomía e eficiencia na práctica diaria da investigación ou da actividade profesional. |
C4 |
CT4 - Apreciar o valor da calidade e mellora continua, actuando con rigor, responsabilidade e ética profesional. |
Learning aims |
Learning outcomes |
Study programme competences / results |
Learning of the biogenetic rules and the function of biomolecules |
AC2 AC3 AC4
|
BC5 BC10 BC11
|
|
Acquisition of advanced knowledge in the chemistry of the most important biomolecules (proteins, nucleic acids and sugars). |
AC1 AC9
|
BC1 BC2 BC4 BC7
|
CC4
|
Learning the more relevant aspects related to the isolation and characterization of biomolecules as well as their synthetic manipulation |
AC2 AC4
|
BC2 BC5 BC7
|
CC1 CC3
|
Contents |
Topic |
Sub-topic |
Chapter 1. Introduction and historical aspects. |
Different components of the cell. Organization. Structure and function of main biomolecules |
CHAPTER 2. Peptides and proteins. Structural aspects. Synthesis and modification. Design of functional proteins. Metalloproteins: types, methods of study, examples and applications |
Amino acids and peptides. Proteins and functions. Primary, secondary, tertiary and quaternary structure. Biosynthesis. Chemical synthesis. Modification by chemical methods. Applications. |
CHAPTER 3. UNIT 3. Nucleic acids: Structure, DNA synthesis. Sequencing, PCR, DNA Recognition. DNA beyond biology: processing and storage of information; nanomaterials. |
Structure of the Nucleotides. Structure and function of the different nucleic acids. Supramolecular chemistry of nucleic acids. Biosynthesis. Synthesis and manipulation of nucleic acids by chemical methods. The interaction with small molecules and metal complexes. |
CHAPTER 4. Carbohydrates and their derivatives. Structural and synthesis. Glycoconjugates and its role in cellular communication. Glycocode. Glycotherapy |
Monosaccharides, nomenclature, structure and chemistry. Oligosaccharides and polysaccharides, nomenclature, structure. Structural determination of oligo-and polysaccharides. Biosynthesis, chemical synthesis and biological synthesis of oligosaccharides. Glycosides and glycosidase inhibitors: types, incidence in nature, methods of synthesis and biological applications. Glycolipids. Types of structures. Natural incidence. Biosynthesis. Functions. Glycoproteins. Types of structures. Natural incidence. Biosynthesis. Functions. The glycocode concept. Future prospects and scope thereof. Glycotherapy and Glycoconjugates known functions. |
Planning |
Methodologies / tests |
Competencies / Results |
Teaching hours (in-person & virtual) |
Student’s personal work hours |
Total hours |
Guest lecture / keynote speech |
B2 B5 C3 C4 |
12 |
24 |
36 |
Problem solving |
B4 B7 B10 B11 |
3 |
17.5 |
20.5 |
Case study |
A2 A4 C1 |
0 |
1 |
1 |
Oral presentation |
B1 B4 B7 B10 B11 C1 |
4 |
0 |
4 |
Mixed objective/subjective test |
A1 A4 A3 A9 B1 B2 B5 |
1.5 |
10 |
11.5 |
|
Personalized attention |
|
2 |
0 |
2 |
|
(*)The information in the planning table is for guidance only and does not take into account the heterogeneity of the students. |
Methodologies |
Methodologies |
Description |
Guest lecture / keynote speech |
There will be 12 magisterial sessions in a group where the theoretical contents of the subject will be included, along with relevant illustrative examples. They will mainly consist of presentations in Power Point. Students will have a copy of all the files in Moodle, so that the students can prepare the classes in advance, as well as facilitate the follow-up of explanations. Interactive participation of students will be encouraged at all times. Active participation in these classes is not mandatory, but it is highly recommended |
Problem solving |
It is proposed to carry out 7 sessions of problem seminars in small groups, where students will solve the problems proposed by the teacher in the corresponding newsletters. Students will have enough time in advance for such newsletters through the Moodle of the subject so that they can be developed individually before the start of these classes. These classes will also resolve any questions that may arise. Participation in these classes is mandatory |
Case study |
In the seminar sessions, the case studies proposed by the teacher will also be solved. Students will have access for such cases enough time in advance through the Moodle of the subject. |
Oral presentation |
Oral presentation by the student of works, reports, etc., including also discussions between the teacher and the students. |
Mixed objective/subjective test |
The final exam will cover all the contents of the course |
Personalized attention |
Methodologies
|
Problem solving |
|
Description |
Tutoring scheduled by the professor and coordinated by the Centre. It will be 2 hours per student and will involve the supervision of proposed work, clarifying doubts, etc. Attendance at these classes is mandatory |
|
Assessment |
Methodologies
|
Competencies / Results |
Description
|
Qualification
|
Mixed objective/subjective test |
A1 A4 A3 A9 B1 B2 B5 |
Or final exam (N2) will cover all subjects. It will weigh 55% on a subject rating. |
55 |
Case study |
A2 A4 C1 |
Within the seminars, a series of evaluable activities will be carried out: Resolution of practical cases, written work and reports |
5 |
Oral presentation |
B1 B4 B7 B10 B11 C1 |
The student will present, orally during the development of the subject, one or more of the results obtained within the activities proposed in the seminars |
5 |
Problem solving |
B4 B7 B10 B11 |
It will consist of two parts: theoretical-practical classes (seminars) and interactive classes in very small groups (tutorials). Within the continuous assessment (N1) this part will weigh 30% in the course mark |
30 |
Guest lecture / keynote speech |
B2 B5 C3 C4 |
The student's participation in the expositive sessions will be assessed, through questions asked by the teacher or through the discussion with the classmates. |
5 |
|
Assessment comments |
The evaluation of this course will be done by means of the
continuous assessment and completion of a final exam. Access
to the exam will be conditioned on the participation in at least 80% of the
mandatory classroom teaching activities (seminars and tutorials).
Continuous assessment (N1) will be 45% of the qualification and
the final exam (N2) will cover all the contents of the course.
The student's score will result of applying the following formula:
Final score = 0.45 x N1
+ 0.55 x N2, N1 and N2 are the marks corresponding to the continuous assessment
(0-10 scale) and the final exam (0-10 scale), respectively.
The repeaters will have the same system of class attendance than
those who study the course for first time.
|
Sources of information |
Basic
|
Davies, B.G.; Fairbanks. A.J. (2004). Carbohydrate Chemistry. Oxford Science publications
Peng G. Wang, C. R. Betozzi. Marcel Dekker (2001). Glycochemistry, Principles, Synthesis and Applications..
Driguez, H; Thiem (1997). Glycoscience, Synthesis of Substrate Analogs and Mimetics.. J. Springer-Verlag
Vranken, D-V; Weiss, G.A. (2012). Introduction to Bioorganic Chemistry and Chemical Biology. Garland Science
Taylor, M.E.; Drickamer, K. (2011). Introduction to Glycobiology. Oxford University press
Brändén, C-I; Tooze, J. (1999). Introduction to Protein Structure. Garland Science
Alberts et all (2002). Molecular Biology of the Cell. Garland Science
Blackburn, M.: Gait, M.J.; Loakes, D.; Williams, D.M. (2006). Nucleic Acids in Chemistry and Biology. Rayal Society of Chemistry
Dr. Norbert Sewald, Prof. em. Dr. Hans-Dieter Jakubke, (2009). Peptides: Chemistry and Biology. John-Wiley
Gutte, B. (1995). Peptides: Synthesis, Structures and Application. Academic Press
D. Serge (1997). The Molecular and Supramolecular Chemistry of Carbohydrates. A chemical introduction to glicoscience.. Oxford Science publications
Chris R. Calladine, Horace R. Drew, Ben F. Luisi and Andrew A. Travers (2004). Understanding DNA, The Molecule & how It Works. Elsevier |
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Complementary
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Recommendations |
Subjects that it is recommended to have taken before |
Advanced Structural Determination/610509103 | Structure and Reactivity of Organic Compounds /610509114 |
|
Subjects that are recommended to be taken simultaneously |
The Chemistry of Natural Products/610509118 | Molecular Biology/610509117 | Medicinal Chemistry/610509116 |
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Subjects that continue the syllabus |
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Other comments |
The students should review the
theoretical concepts introduced in each chapter using the reference manual and
the material provided by the professor. Those students, which have significant
difficulties when working the proposed activities, should contact with the
professor during the tutorials, in order to analyze the problem and to receive
the necessary support.The professor will analyze
with those students who do not successfully pass the evaluation their difficulties in learning. Additional material
(questions, exercises, tests, etc..) to strengthen the learning of the course
might be also provided. |
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