Study programme competencies |
Code
|
Study programme competences / results
|
A1 |
Ability to use chemistry terminology, nomenclature, conventions and units |
A5 |
Understanding of principles of thermodynamics and its applications in chemistry |
A9 |
Knowledge of structural characteristics of chemical and stereochemical compounds, and basic methods of structural analysis and research |
A10 |
Knowledge of chemical kinetics, catalysis and reaction mechanisms |
A12 |
Ability to relate macroscopic properties of matter to its microscopic structure |
A13 |
Understanding of chemistry of main biological processes |
A15 |
Ability to recognise and analyse new problems and develop solution strategies |
A16 |
Ability to source, assess and apply technical bibliographical information and data relating to chemistry |
A20 |
Ability to interpret data resulting from laboratory observation and measurement |
A21 |
Understanding of qualitative and quantitative aspects of chemical problems |
A22 |
Ability to plan, design and develop projects and experiments |
A23 |
Critical standards of excellence in experimental technique and analysis |
A24 |
Ability to explain chemical processes and phenomena clearly and simply |
A25 |
Ability to recognise and analyse link between chemistry and other disciplines, and presence of chemical processes in everyday life |
B1 |
Learning to learn |
B2 |
Effective problem solving |
B3 |
Application of logical, critical, creative thinking |
B4 |
Working independently on own initiative |
B5 |
Teamwork and collaboration |
B7 |
Effective workplace communication |
C1 |
Ability to express oneself accurately in the official languages of Galicia (oral and in written) |
C3 |
Ability to use basic information and communications technology (ICT) tools for professional purposes and learning throughout life |
C4 |
Self-development as an open, educated, critical, engaged, democratic, socially responsible citizen, equipped to analyse reality, diagnose problems, and formulate and implement informed solutions for the common good |
C6 |
Ability to assess critically the knowledge, technology and information available for problem solving |
Learning aims |
Learning outcomes |
Study programme competences / results |
As a result of learning it is expected that students know the nomenclature of the usual functional groups in biomolecules and biochemical terminology , measurement units , international conventions and classification models representing biomolecules |
A1 A9 A12 A15 A21 A25
|
B1 B2 B3 B4
|
|
The students will understand the mechanisms transmission of transmission of genetic information: replication, transcription and translation. They will understand the importance of molecular biology in scientific and technological development. |
A13 A16 A21 A24
|
B1
|
C3 C6
|
The student will understand enzymatic catalysis. The peculiarities of enzymes as catalysts. The concept of catalytic center, reaction mechanisms, enzymatic catalysis processes, the kinetics of the reactions catalyzed by enzymes and enzymatic regulation in response to metabolic and hormonal changes. Solve problems related to these contents. |
A1 A10 A13 A15 A20 A21 A24
|
B1 B2 B3 B4
|
|
The students will understand the systems of generation, storage and trasnferencia of energy in the cell, the application of the principles of thermodynamics and its applications in the chemistry of living organisms; and solving problems related to these contents. |
A5 A13 A24 A25
|
B1 B2 B3 B4
|
|
To know general concepts of metabolic processes and their regulation and their interconnections. Understanding of the role of the control of enzyme regulation on metabolic pathways. To know how to use the right language for the description of the metabolic processes. To be able to solve problems related to metabolic flow diagrams, to do balances and metabolic studies by labeling metabolites.
|
A13 A15 A24 A25
|
B1 B2 B3 B4
|
|
To knowi the apparatus, instruments and basic protocols in the biochemistry laboratory. Implement the theoretical knowledge of the subject. Interpret the results, and propose alternative methods; properly express the results in a lab report. To work with security, and develops skills for systematic methods and excellence in laboratory work. |
A9 A10 A13 A15 A16 A20 A21 A22 A23
|
B1 B3 B4 B5 B7
|
C1 C4
|
Contents |
Topic |
Sub-topic |
1.- Biomolecules. Structure, characteristics and chemical reactivity |
Structure of biomolecules: Configuration and conformation. Isomerism: Concept and types. Carbohydrates: Nomenclature and structure; classification and importance. Lipids: Concept, classification and importance; Nomenclature and structure. Properties of proteins in solution. Parameters characterizing a protein and techniques for determination. Primary, secondary, tertiary and quaternary structure. Fibrous and globular proteins. Folding. Conformers in the spatial organization of nucleic acids. Parameters characterizing a nucleic acid and determination. De-naturation and re-naturation. Biochemical techniques used for the isolation and purification of biomolecules. |
2.-Genetic information |
Replication and transcription of DNA: DNA and RNA biosynthesis. Protein translation: genetic code and protein metabolism. |
3.-Structure and function of macromolecules and biological membranes. |
The interaction of proteins with ligands and conformational changes. The concept of cooperativity and models. Conjugated proteins: Union to metals, to prosthetic groups, to glycids, to lipids. Interactions between nucleic acids and proteins. Structure and properties of the membranes. |
4.-Catalysis and control of biochemical reactions. |
Enzyme purification. Purification parameters and tables. Units of enzymatic activity. The methods to measure EU. Coupled- Assays. Catalysis as a model of the enzyme-substrate interaction. Catalytic centers. Specificity. Coenzymes and their involvement in catalysis. The concept of enzymatic regulation. Models. Allosterism. Isoenzymes. Multienzyme complexes. The kinetics of enzymatic reactions. Calculation of kinetic parameters in mono and bi-substrate reactions. Kinetics in the presence of inhibitors. Inhibition constants calculation. The kinetics of allosteric enzymes. |
5 - The role of metals in biological systems |
Iron in biological molecules: heme group and siro-heme, Fe-S and Fe-SO centers. Transport and storage of Fe: Transferrin and Ferritin. Siderophores. The copper in biological systems: Structure of different types of complexes with Cu and containing proteins. Other complexes with trace elements. Metal toxicity. Metals in medicine. |
6.-Bio-energetics |
Systems of energy transfer between the reactions. Exchange systems of phosphate groups; systems based on the use of co-enzyme and re-dox reactions. The problems associated with cellular compartments: shuttle systems. |
7.- Metabolism. |
Introduction to Metabolism. Metabolic pathways of degradation. Metabolic pathways of biosynthesis. Peculiarities of chemical reactions in biological systems. Interaction and regulation of biological reactions. Case studies of interpretation of reactions in metabolic pathways. Glycolysis, TCA cycle. Fermentations. Pentose Phosphate pathway. Glioxalate cicle. Beta-oxidation. Biosynthesis of Palmitoleic acid. Urea cycle. |
Planning |
Methodologies / tests |
Competencies / Results |
Teaching hours (in-person & virtual) |
Student’s personal work hours |
Total hours |
Guest lecture / keynote speech |
A1 A5 A9 A10 A12 A13 A24 A25 B1 C3 |
25 |
49 |
74 |
Laboratory practice |
A1 A9 A10 A15 A20 A21 A22 A23 B1 B2 B3 B4 B5 B7 |
10 |
5 |
15 |
Problem solving |
A1 A5 A9 A10 A12 A13 A15 A16 A20 A21 A24 A25 B1 B2 B3 B4 B5 B7 C1 C3 C4 C6 C8 |
9 |
27 |
36 |
Diagramming |
A16 B1 B4 C3 |
1 |
18 |
19 |
Mixed objective/subjective test |
A1 A5 A9 A10 A12 A13 A24 A25 B2 C1 |
4 |
0 |
4 |
|
Personalized attention |
|
2 |
0 |
2 |
|
(*)The information in the planning table is for guidance only and does not take into account the heterogeneity of the students. |
Methodologies |
Methodologies |
Description |
Guest lecture / keynote speech |
Oral presentation complemented by the use of audiovisual media about chemical biological processes in order to build the capacity of understanding of the issues by the students.
|
Laboratory practice |
The students will work in the lab experimentally setting up various techniques related to the subject of the isolation, characterization and identification of biomolecules. They will learn to work in the laboratory in accordance with safe and reproducible patterns. They also will learn how to present and interpret the results and discuss them according to knowledge acquired in the theoretical part of the subject by preparing a lab report. |
Problem solving |
With the resolution of practical problems and work with molecular models will delve into the practical application of the concepts explained in the lectures and will take advantage of the smaller size of the group to generate questions to help reflection and personal involvement of students in the process of learning. |
Diagramming |
Diagrams of the metabolic routes |
Mixed objective/subjective test |
Trial combining different types of questions to assess the knowledge acquired in the various activities undertaken.
PARTIAL (date stablished in the scholar calendar)
It is not mandatory, it is eliminatory
|
Personalized attention |
Methodologies
|
Laboratory practice |
Problem solving |
Diagramming |
|
Description |
Personal attention will be conducted throughout the course and at any time requested by the student.
The working, development of supervised works will be guided by the teacher through personal tutorials, as well as resolving any questions that could arise during this activity.
Students with part-time dedication or waiver of presence should contact the teachers of the subject in the early going to establish a schedule of activities to acquire and evaluate in a complementary way the competences. |
|
Assessment |
Methodologies
|
Competencies / Results |
Description
|
Qualification
|
Laboratory practice |
A1 A9 A10 A15 A20 A21 A22 A23 B1 B2 B3 B4 B5 B7 |
It is: the work developed in the laboratory, the formulation of the results and the results of a test that includes all aspects learned in the laboratory.
Attendance is mandatory
Participation is valued at 5 points
The test is valued at 5 points |
10 |
Mixed objective/subjective test |
A1 A5 A9 A10 A12 A13 A24 A25 B2 C1 |
Evaluation of the knowledge and skills acquired during course development including master classes, group activities, and practices.
The proportion in the evaluation will be:
Tracks 1-4: 40 points (eliminatory with 20 points)
Tracks 5-7: 40 points
|
80 |
Problem solving |
A1 A5 A9 A10 A12 A13 A15 A16 A20 A21 A24 A25 B1 B2 B3 B4 B5 B7 C1 C3 C4 C6 C8 |
Active participation in groups that let you work these skills valued up to 5 points
The completion of the metabolic scheme is valued up to 5 points |
10 |
|
Assessment comments |
Practical work is mandatory to pass the course and qualification. Omission of the practical work means having to overcome a practical exam in the laboratory about the techniques performed.
1.-
Continuous evaluation: assistance, autonomous work and participation in scheduled activities is valued. The student has to reach 50% in the sum of the parts to pass. The first exam is not obligatory.
2. Overall evaluation. In
the July / June options, the student (without taking into account the grades obtained during the course) will do only a theoretical
final exam (90%) and a practical laboratory exam (10%). You have to notify in writing to the teacher of the subject this option
before May 15 for both the first and second choice for the exams (June or July). Students with part-time dedication or waiver attendance may choose to
be evaluated in this mode if they do not qualify for continuous evaluation. The student has to reach 50% in the sum of the parts to pass.
Following the rules of qualifications and records in Masters Degrees proposed by the
Commission of Quality of the Faculty of Sciences, the
Distinction MH will be awarded preferably to those students who obtain the
highest marks (outstanding) in the first choice of assessment (June).
|
Sources of information |
Basic
|
|
BIBLIOGRAFÍA BÁSICA
· VOET, VOET, PRAT. Fundamentos de Bioquímica. 2ª Edición. Panamericana, (2007)
BIBLIOGRAFÍA COMPLEMENTARIA
Otros libros disponibles en la biblioteca que puede ser útil consultar si no se dispone del texto recomendado:
· CAMPBELL, M.K. Y FARRELL, S.O. Bioquímica, 4ª edición. Thomsom, (2004).
· RODNEY, BOYER. Conceptos de Bioquímica. International THOMSON Editores. (2000).
· LEHNINGER. Principios de Bioquímica 2ª edición. Omega. (1995).
· MATHEWS, C.K. y VAN HOLDE, K.E. Bioquímica. 2ª edición. McGraw-Hill. (1998).
· RAWN, J. Bioquímica. Tomos I y II. McGraw-Hill. (1989).
· STRYER, L. Bioquímica IV Edición. Tomos I y II. Ed. Reverté. (1995).
· LEHNINGER. Principios de Bioquímica 3ª edición. Omega. (2001).
· MATHEWS C. K., VAN HOLDE, K. E. y AHERN, K. G. Bioquímica 3ª Edición Addison- Wesley. (2003).
· METZLER, D. E. Biochemistry: The chemical reactions of living cells. 2nd Ed. Harcourt. Academic Press. (2001).
|
Complementary
|
|
|
Recommendations |
Subjects that it is recommended to have taken before |
|
Subjects that are recommended to be taken simultaneously |
|
Subjects that continue the syllabus |
|
Other comments |
It is essential to participate in classes and activities as well as work every day with the support of the recommended bibliography taht will help to better understanding and comprehension of the subject study. Continued assistance is recommended since there will be classes for solving exercises and scoring experimental problems will help the study and preparation of the final examination by the student. Also attending tutorials to resolve questions and issues on the agenda that are of particular difficulty for the student is advised. |
|