Identifying Data 2018/19
Subject (*) Fundamentals of bioinformatics Code 614522008
Study programme
Mestrado Universitario en Bioinformática para Ciencias da Saúde
Descriptors Cycle Period Year Type Credits
Official Master's Degree 1st four-month period
First Obligatory 6
Language
English
Teaching method Face-to-face
Prerequisites
Department Ciencias Biomédicas, Medicina e Fisioterapia
Computación
Coordinador
Munteanu , Cristian Robert
E-mail
c.munteanu@udc.es
Lecturers
Munteanu , Cristian Robert
Pereira Loureiro, Javier
E-mail
c.munteanu@udc.es
javier.pereira@udc.es
Web http://moodle.udc.es
General description Esta materia impártese en inglés. Expóñense os conceptos sobre os principios básicos da anotación do xenoma, o análise de secuencias, as ferramentas de procesamento de información molecular, as ferramentas para deseño de fármacos e a avaliación da toxicidade, as bases de datos biolóxicas, omics e epixenética, os proxectos Xenoma humano, Varioma e Exposoma, e as aplicacións de bioinformática en la clínica.


Competencies
STUDY PROGRAMME COMPETENCES
TypeA Code  
  Job guided
  AJ1 CE1 - Ability to know the scope of Bioinformatics and its most important aspects
  AJ6 CE6 - Ability to identify software tools and most relevant bioinformatics data sources, and acquire skill in their use
  AJ7 CE7 - Ability to identify the applicability of the use of bioinformatics tools to clinical areas.
TypeB Code  
  Job guided
  BJ1 CB6 - Own and understand knowledge that can provide a base or opportunity to be original in the development and/or application of ideas, often in a context of research
  BJ2 CB7 - Students should know how to apply the acquired knowledge and ability to problem solving in new environments or little known within broad (or multidisciplinary) contexts related to their field of study
  BJ3 CB8 - Students to be able to integrate knowledge and deal with the complexity of making judgements from information that could be incomplete or limited, including reflections on the social and ethical responsibilities linked to the application of their skills and judgments
  BJ5 CB10 - Students should possess learning skills that allow them to continue studying in a way that will largely be self-directed or autonomous.
  BJ6 CG1 -Search for and select the useful information needed to solve complex problems, driving fluently bibliographical sources for the field
  BJ7 CG2 - Maintain and extend well-founded theoretical approaches to enable the introduction and exploitation of new and advanced technologies
  BJ8 CG3 - Be able to work in a team, especially of interdisciplinary nature
TypeC Code  
  Job guided
  CJ1 CT1 - Express oneself correctly, both orally writing, in the official languages of the autonomous community
  CJ2 CT2 - Dominate the expression and understanding of oral and written form of a foreign language
  CJ3 CT3 - Use the basic tools of the information technology and communications (ICT) necessary for the exercise of their profession and lifelong learning
  CJ6 CT6 - To assess critically the knowledge, technology and information available to solve the problems they face to.
  CJ8 CT8 - Rating the importance that has the research, innovation and technological development in the socio-economic and cultural progress of society

Learning aims

Contents
Topic Sub-topic
Basic principles for Genome Annotation
Sequence analysis
Processing tools of molecular information
Tools for drug design and evaluation of toxicity
Biological databases
Omics and epigenetics: genomics, proteomics, transcriptomics
Projects: Human Genome, Variome, Exposome
Bioinformatics applications in clinical practice
.

Planning
Methodologies / tests Competencies Ordinary class hours Student’s personal work hours Total hours
ICT practicals A1 A6 A7 B1 B2 B3 B5 B6 B7 B8 C1 C2 C3 C6 C8 30 30 60
Oral presentation A1 C1 C2 C3 C6 C8 5 5 10
Supervised projects A1 C1 C2 C3 C6 C8 10 10 20
Objective test A1 A6 A7 B1 B2 B3 B5 B6 B7 B8 C1 C2 C3 C6 C8 1 14 15
Guest lecture / keynote speech A1 A6 A7 B1 B2 B3 B5 B6 B7 B8 C1 C2 C3 C6 C8 20 20 40
 
Personalized attention 5 0 5
 
(*)The information in the planning table is for guidance only and does not take into account the heterogeneity of the students.

Methodologies
Methodologies Description
ICT practicals Laboratory practice
Oral presentation Public presentation of the supervised work
Supervised projects Practical work on the theoretical content of the course
Objective test Exam on the theoretical content and supervised work carried out throughout the course. This test could be replaced by the supervised work.
Guest lecture / keynote speech Theoretical lessons in the classroom

Personalized attention
Methodologies
Supervised projects
Objective test
Oral presentation
Guest lecture / keynote speech
ICT practicals
Description
To solve the most complex aspects of the course, individual or group tutorials with students will be held.

Assessment
Methodologies Competencies Description Qualification
Supervised projects A1 C1 C2 C3 C6 C8 The proposed work on the subject will be part of the evaluation. 30
Objective test A1 A6 A7 B1 B2 B3 B5 B6 B7 B8 C1 C2 C3 C6 C8 If deemed necessary, a test on the theoretical and practical content of the course (including the topics of the lectures and publicly exposed supervised projects) may be conducted. The teacher can distribute points of this test among other methods if deemed appropriate. 30
Oral presentation A1 C1 C2 C3 C6 C8 The public presentation of the supervised work will be part of the final assessment. 30
ICT practicals A1 A6 A7 B1 B2 B3 B5 B6 B7 B8 C1 C2 C3 C6 C8 The quality and delivery in time of the practices will be assessed. 10
 
Assessment comments

To pass this course, the student needs to obtain a minimum percentage in each of the methodologies.


Sources of information
Basic Stekel, Dov. (2003). Microarray bioinformatics. Cambridge: Cambridge University Press, 2003
Ohlebusch, Enno (2013). Bioinformatics algorithms : sequence analysis, genome rearrangements, and phylogenetic reconstruction. Ulm : Oldenbusch Verlag
Dan E. Krane, Michael L. Raymer (2003). Fundamental concepts of bioinformatics. San Francisco, California : Benjamin Cummings
Edward Keedwell and Ajit Narayanan (2005). Intelligent bioinformatics the application of artificial intelligence techniques to bioinformatics problems. Chichester : John Wiley & Sons

Graph-based Processing of Macromolecular Information, Current Bioinformatics 10(5): 606-631 (2016), DOI: 10.2174/1574893610666151008012438 | Cristian R. Munteanu, Vanessa Aguiar-Pulido, Ana Freire, Marcos Martínez-Romero, Ana B. Porto-Pazos, Javier Pereira, Julian Dorado | online


RRegrs: An R package for Computer-aided Model Selection with Multiple Regression Models, Journal of Cheminformatics  7(1), 1-16, doi:10.1186/s13321-015-0094-2 (2015) | Georgia Tsiliki, Cristian R. Munteanu, Jose A Seoane, Carlos Fernandez-Lozano, Haralambos Sarimveis, Egon L. Willighagen | GitHub| 10.5281/zenodo.21946 | online 

Bio-AIMS Collection of Chemoinformatics Web Tools based on Molecular Graph Information and Artificial Intelligence Models, Combinatorial Chemistry & High Throughput Screening 18(8):735-50 (2015) | Cristian R. Munteanu, Humberto González-Díaz, Rafael García, Mabel Loza, Alejandro Pazos | online 

S2SNet: A Tool for Transforming Characters and Numeric Sequences into Star Network Topological Indices in Chemoinformatics, Bioinformatics, Biomedical, and Social-Legal sciences, Current Bioinformatics 8(4), 429-437 (2013) | Cristian R. Munteanu, Alexandre L Magalhães, Aliuska Duardo Sánchez, Alejandro Pazos, Humberto González-Díaz | online

Tutorial Biopython: http://biopython.org/DIST/docs/tutorial/Tutorial.html
Complementary



Recommendations
Subjects that it is recommended to have taken before

Subjects that are recommended to be taken simultaneously

Subjects that continue the syllabus

Other comments

Materia impartida en inglés



(*)The teaching guide is the document in which the URV publishes the information about all its courses. It is a public document and cannot be modified. Only in exceptional cases can it be revised by the competent agent or duly revised so that it is in line with current legislation.