Study programme competencies |
Code
|
Study programme competences / results
|
A1 |
Define concepts, principles, theories and specialized facts of different areas of chemistry. |
A3 |
Innovate in the methods of synthesis and chemical analysis related to the different areas of chemistry |
A4 |
Apply materials and biomolecules in innovative fields of industry and chemical engineering. |
B2 |
Students should apply their knowledge and ability to solve problems in new or unfamiliar environments within broader (or multidisciplinary) contexts related to their field of study. |
B4 |
Students should be able to communicate their conclusions, and the knowledge and the reasons that support them to specialists and non-specialists in a clear and unambiguous manner |
B5 |
Students must possess learning skills to allow them to continue studying in a way that will have to be largely self-directed or autonomous. |
B7 |
Identify information from scientific literature by using appropriate channels and integrate such information to raise and contextualize a research topic |
B10 |
Use of scientific terminology in English to explain the experimental results in the context of the chemical profession |
B11 |
Apply correctly the new technologies to gather and organize the information to solve problems in the professional activity. |
C1 |
CT1 - Elaborar, escribir e defender publicamente informes de carácter científico e técnico |
C3 |
CT3 - Traballar con autonomía e eficiencia na práctica diaria da investigación ou da actividade profesional. |
C4 |
CT4 - Apreciar o valor da calidade e mellora continua, actuando con rigor, responsabilidade e ética profesional. |
Learning aims |
Learning outcomes |
Study programme competences / results |
Acquisition of advanced knowledge in the chemistry of Natural Products, from both terrestrial and marine origin |
AC1
|
BC2 BC4 BC7
|
CC1 CC3 CC4
|
Learning of the most important applications, mainly as drugs and as tools in biomedical research |
AC3 AC4
|
BC2 BC5
|
CC1 CC4
|
Learning of the main biogenetic routes and the main metabolites that originate |
AC1
|
BC2 BC7
|
CC1 CC4
|
Learning of the modern techniques used for their isolation and identification |
AC4
|
BC10 BC11
|
CC1 CC4
|
Contents |
Topic |
Sub-topic |
CHAPTER 1. Introduction to the study of natural products |
Concepts of natural product and secondary metabolite. Main natural sources. Main applications. Importance of natural products in the pharmaceutical industry. Classification and examples. |
CHAPTER 2. Main metabolic pathways of the secondary metabolism |
General scheme of secondary metabolism, main types of natural products that originate and classification based on metabolic pathways. Main mechanisms of biological pathways. Methods of elucidation of a metabolic route. |
CHAPTER 3. Metabolites derived from acetate: poliketides, fatty acids and related compounds |
Metabolites derived from acetate: poliketides, fatty acids and related compounds. |
CHAPTER 4. Metabolites derived from mevalonate: terpenes and steroids |
Metabolites derived from mevalonate: terpenes and steroids. |
CHAPTER 5. Metabolites derived from shikimic acid |
Biosynthetic origen of shikimic acid. Phenylpropanoids. Metabolites of mixed origin: Flavonoids. |
CHAPTER 6. Natural nitrogenous compounds |
Aliphatic alkaloids: derivates from lysine and ornithine. Aromatic alkaloids: derivates from phenylalanine/tyrosine and tryptophan. Other estructural frameworks. Biosynthesis of non ribosomal peptides. |
CHAPTER 7. Modernas estrategias de aislamiento e identificación |
Traditional methods. Dereplication techniques. Biotechnology strategies based on genetic studies: Genome mining, recombinant biosynthesis and combinatorial biosynthesis. |
Planning |
Methodologies / tests |
Competencies / Results |
Teaching hours (in-person & virtual) |
Student’s personal work hours |
Total hours |
Guest lecture / keynote speech |
B2 B5 C3 C4 |
12 |
24 |
36 |
Problem solving |
B4 B7 B10 B11 |
6 |
17.5 |
23.5 |
Case study |
B4 B7 B10 B11 C1 |
0 |
1 |
1 |
Oral presentation |
B4 B7 B10 B11 C1 |
1 |
0 |
1 |
Mixed objective/subjective test |
A1 A4 A3 B2 B5 |
1.5 |
10 |
11.5 |
|
Personalized attention |
|
2 |
0 |
2 |
|
(*)The information in the planning table is for guidance only and does not take into account the heterogeneity of the students. |
Methodologies |
Methodologies |
Description |
Guest lecture / keynote speech |
It will be held 12 sessions of lectures in one group where the theoretical contents of the course will be associated with illustrative examples. It will consist mainly in PowerPoint presentations. Copies of these presentations will be available for the students in advance via the virtual campus of the course. This will allow the students to study ahead the contents of the course and to facilitate the monitoring of explanations |
Problem solving |
7 sessions in small group seminars where students will present the work proposed by the professor followed by a discussion section. Students will have in advance the proposed exercises and papers via the virtual campus of the course. Attendance at these classes is mandatory |
Case study |
The student will carry out a work on a topic that was selected by the teacher and he will prepare the corresponding written report that will be given to the teacher for evaluation. |
Oral presentation |
The student will present in a seminar class the work in the presence of the teacher and the rest of the students. |
Mixed objective/subjective test |
The final exam will cover all the contents of the course |
Personalized attention |
Methodologies
|
Problem solving |
|
Description |
Tutoring scheduled by the professor and coordinated by the Centre. It will be 2 hours per student and will involve the supervision of proposed work, clarifying doubts, etc. Attendance at these classes is mandatory |
|
Assessment |
Methodologies
|
Competencies / Results |
Description
|
Qualification
|
Problem solving |
B4 B7 B10 B11 |
They will consist of two components: interactive class in problems solving clases (seminars) and interactive class in very small groups (tutorials).
This part within the continuous assessment (N1) will be 40% of the qualification |
30 |
Guest lecture / keynote speech |
B2 B5 C3 C4 |
Attendance at these classes is mandatory.
The missed classes must be justified
This part within the continuous assessment (N1) will be 10% of the qualification |
5 |
Mixed objective/subjective test |
A1 A4 A3 B2 B5 |
The final exam (N2) will cover all the contents of the course.
This part will be 60% of the qualification. |
55 |
Case study |
B4 B7 B10 B11 C1 |
The report assigned to the student by the teacher will be evaluated |
5 |
Oral presentation |
B4 B7 B10 B11 C1 |
The presetation of the work by the student will be evaluated with particular regard to the clarity of the exposition, scientific rigor of the exposed content and that respond correctly to the questions that will be asked after the presentation. |
5 |
|
Assessment comments |
The evaluation of this course will be done by means of the continuous evaluation and completion of a final exam. Access to the exam will be conditioned on the participation in at least 80% of the mandatory classroom teaching activities (seminars and tutorials).
Continuous evaluation (N1) will be 45% of the qualification and the final exam (N2) will cover all the contents of the course. The student's score will result of applying the following formula: Final score = 0.45 x N1 + 0.55 x N2. N1 and N2 are the marks corresponding to the continuous assessment (0-10 scale) and the final exam (0-10 scale), respectively. The repeater students will have the same system of class attendance than those who study the course for
|
Sources of information |
Basic
|
Paul M. Dewick (2009). Medicinal Natural Products. A Biosynthetic Approach. 3ª. ed.”, Wiley, Wiltshire
S. D. Sarker, L. Nahar (2012). Natural Products Isolation. New Jersey: Human Press
Jonathan Clayden, Nick Greeves, Stuart Warren (2012). Organic Chemistry. New York: University Press
Pilar Gil Ruiz (). Productos naturales. Pamplona: Universidad Pública de Navarra
J. Alberto Marco (2006). Química de los productos naturales. Madrid: Síntesis
J. Mann (1992). Secondary Metabolism. Oxford: Oxford Science Publications
Richard B. Herbert (1989). The biosynthesis of secondary metabolites. London: Chapman and Hall |
|
Complementary
|
Ana M. Lobo, Ana M. Lourenco (2007). Biossíntese de productos naturais. Lisboa: IST Press
Edwin Haslam (1993). Shikimic Acid: Metabolism and Metabolites. Chichester: John Wiley & Sons |
|
Recommendations |
Subjects that it is recommended to have taken before |
Advanced Structural Determination/610509103 | Structure and Reactivity of Organic Compounds /610509114 |
|
Subjects that are recommended to be taken simultaneously |
Chemistry of Biomolecules/610509115 | Stereoselective Synthesis/610509113 |
|
Subjects that continue the syllabus |
|
Other comments |
The students should review the theoretical concepts
introduced in each chapter using the reference manual and the material provided
by the professor. Those students, which have significant difficulties when working the proposed activities,
should contact with the professor during the tutorials,
in order to analyze the problem and to receive the
necessary support. The professor will analyze with those students
who do not successfully pass the evaluation,
and so wish, their difficulties in learning the course
content. Additional material (questions,
exercises, tests, etc..) to strengthen the learning of the course might be also
provided. |
|