Laboratory practices are mandatory.To pass the subject, the student must obtain at least 50% of the score assigned to the essay / development test and another 50% of that of the laboratory practices.It will be considered NOT PRESENTED when the student has not participated in more than 20% of the scheduled assessable activities. This criterion applies to the January call. In the July call, to obtain the grade NOT PRESENTED, it will be enough to not appear for the objective tests (theory and practical exams).For the evaluation of the July call, the student, in addition to the corresponding exams, must present the power point presentation of the oral presentation. In the event that this activity was already evaluated in the January call, the grade obtained will remain for July.For students with part-time dedication and exemption from attendance, the teacher will adopt the measures that he deems appropriate to avoid damaging her grade (flexibility in the delivery dates of the assessable activities). Instead of the oral presentation, these students will make a 2-3 page summary that must be delivered in pdf to the teacher for evaluation.&nbsp;

Learning outcomes	Study programme competences
Comprehensive reading of scientific texts related to the module subjects Ability to expose the current state of knowledge within this field Critical ability to evaluate hypotheses and interpret results Understanding cell structure and function from an interdisciplinary vision in which Cell Biology, classical Cytology, Genetics and Molecular Biology converge Understanding of the biochemical and physiological processes that allow signaling between cells and with structural elements, as well as the causative aspects of pathologies related to alterations in cell signaling and the tools used for your study Know the experimental techniques to access the study of the molecular mechanisms of regulation of gene expression as well as the molecular machinery involved and their regulatory systems To know the characteristics of the proteins and complexes involved in the regulation of gene expression, their interaction with genetic material and the enzymatic reactions that modulate their activity. To know the mechanisms that cause genetic variability	AR3 AR6 AR11 AR12 AR13	BR1 BR2	CC2 CC3

Topic	Sub-topic
Topic 1. Nature of mutations.	Estimates of mutation rate and frequency. Types of lesions caused by mutations. Physical and chemical mutagens. Reversion and deletion. Paramutation.
Topic 2. DNA repair mechanisms.	Preventive methods. Direct repair. Excision repair. Post-replication repair.
Topic 3. Genetic diseases related to mutagenic agents.	Cancer. Diseases due to failures in repair systems.
Topic 4. Mobile DNA:	abundance in genomes. Classifications of transposable elements. Proliferation. Modular evolution. Impact on genomes. Domestication.
Topic 5. Recombination processes.	Recombination rates. Gene conversion. Sexual dimorphism of the rate of recombination, crossing over and gene conversion. Biased gene conversion.
Topic 6. Evolution of scientific thinking about the origin of genetic variability. The contribution of Woese.	Introduction: Cell evolution: the "bumpy" path to "who knows where" History of evolutionary thought: Lamarck History of evolutionary thought: Darwin History of evolutionary thought: Modern Synthesis of Evolutionary Biology State of Microbiology (and Virology) for most of the 20th century Carl Woese LUCA Generation of genetic variability in the beginning of life
Unit 7. Microbial evolution in the era of genomics	Introduction The turbulent dynamics of microbial evolution HGT Damned concepts of classical genetics: genetic elements with Lamarckian flavor? Damned concepts of classical genetics: Evolution of evolution?
Unit 8. The mysterious world of viruses	Introduction figures and definitions Are the viruses alive? Early ideas about the evolution of viruses Structural biology allows a deep look into the past The origin of viral replicons When did viruses originate? Gene flow between viruses and hosts New discoveries about the evolution of viruses Viral population dynamics models conclusions

Methodologies / tests	Competencies	Ordinary class hours	Student’s personal work hours	Total hours
Guest lecture / keynote speech	A3 A6 A11 A12 A13 B1 B2 C2 C3	0	36	36
Long answer / essay questions	C2 C3	2	8	10
Multiple-choice questions	C2 C3	8	0	8
Workbook	A6 A11 A12 B1 B2 C2 C3	0	14	14
Laboratory practice	A12 A13 B1 B2 C2 C3	6	0	6

Personalized attention		4	0	4

(*)The information in the planning table is for guidance only and does not take into account the heterogeneity of the students.

Methodologies	Description
Guest lecture / keynote speech	In each class the contents of the program will be exposed. The teachers' presentations will be incorporated into the Moodle platform. CONTINGENCY PLAN: the lectures will be held via TEAMS at the previously approved official hours
Long answer / essay questions	Written test in which any aspect addressed in the theoretical and practical teaching will be dealt with. CONTINGENCY PLAN: PRESENTIAL students will take the exam via TEAMS on the date and times previously established and approved
Multiple-choice questions
Workbook
Laboratory practice	The laboratory practices are the following: Practice 1: PCR amplification of DNA sequences Practice 2: electrophoresis of PCR products Practice 3: Work with bioinformatics tools for the analysis of the sequences of the PCR products CONTINGENCY PLAN: in case of confinement, the practices will be reconverted or replaced in computer analysis working with different genomic sequences.

Methodologies	Competencies	Description	Qualification
Long answer / essay questions	C2 C3	Test de resposta múltiple sobre os contenidos teóricos e prácticos. Cando menos o 50% da proba será en inglés. Nesta actividade avaliarase a adquisición das competencias A5, A9, A16.	70
Laboratory practice	A12 A13 B1 B2 C2 C3	Attendance to lab sessions and execution of exercises proposed by the teacher will be graded. For the monitoring and grading of learning, students must prepare and present a practical notebook with its introduction, materials and methods, description of results and conclusions. In this activity the acquisition of competence A5 will be evaluated.	15

Assessment comments
<p>Laboratory practices are mandatory.</p><p>To pass the subject, the student must obtain at least 50% of the score assigned to the essay / development test and another 50% of that of the laboratory practices.</p><p>It will be considered NOT PRESENTED when the student has not participated in more than 20% of the scheduled assessable activities. This criterion applies to the January call. In the July call, to obtain the grade NOT PRESENTED, it will be enough to not appear for the objective tests (theory and practical exams).</p><p>For the evaluation of the July call, the student, in addition to the corresponding exams, must present the power point presentation of the oral presentation. In the event that this activity was already evaluated in the January call, the grade obtained will remain for July.</p><p>For students with part-time dedication and exemption from attendance, the teacher will adopt the measures that he deems appropriate to avoid damaging her grade (flexibility in the delivery dates of the assessable activities). Instead of the oral presentation, these students will make a 2-3 page summary that must be delivered in pdf to the teacher for evaluation.</p><p>&nbsp;</p>

Basic	Gibson, G. (2009). A primer of genome science. Sinauer Associates E.C. Friedberg et al. (2006). DNA repair and mutagenesis. Second edition. ASM Press Weiner, M. P., Gabriel, S., and Claibo, J. (2007). Genetic variation: a laboratory manual. Cold Spring Harbor Laboratory Press Meyers, R. A. (2007). Genomics and genetics: from molecular details to analysis and techniques. Wiley-VCH N L Craig et al. (2002). Mobile DNA II. ASM Press
	The students will receive from the teachers of the subject recent webgraphy and review articles to properly prepare the subject. They will be hosted (bibliography and webgraphy) on the Moodle platform.
Complementary	R Scott Hawley, MY Walker (2003). Advanced genetic analysis. Finding meaning in a genome. . Blackwell Publishing Hartl, D. L. (2009). Genetics: analysis of genes and genomes. Jones and Bartlett Watson et al. (2004). Molecular Biology of the gene. Fifth edition. Pearson-Cummings J. M. Coffin et al. (1997). Retroviruses. Cold Spring Harbor Laboratory Press