Study programme competencies |
Code
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Study programme competences
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A1 |
Skills of working in a sure way in the laboratories knowing operation handbooks and actions to avoid incidents of risk. |
A6 |
Skills of understanding the functioning of cells through the structural organization, biochemistry, gene expression and genetic variability. |
A8 |
Skills of having an integrated view of the previously acquired knowledge about Molecular and Cellular Biology and Genetics, with an interdisciplinary approach and experimental work. |
A11 |
Skills of understanding the structure, dynamics and evolution of genomes and to apply tools necessary to his study. |
A12 |
Skills to understand, detect and analyze the genetic variation, knowing genotoxicity processes and methodologies for its evaluation, as well as carrying out diagnosis and genetic risk studies. |
B1 |
Analysis skills to understand biological problems in connection with the Molecular and Cellular Biology and Genetics. |
B3 |
Skills of management of the information: that are able to gather and to understand relevant information and results, obtaining conclusions and to prepare reasoned reports on scientific and biotechnological questions |
B5 |
Ability to draft, represent, analyze, interpret and present technical documentation and relevant data in the field of the branch of knowledge of the master's degree in the native language and at least in another International diffusion language. |
B6 |
Skills of team work: that are able to keep efficient interpersonal relationships in an interdisciplinary and international work context, with respect for the cultural diversity. |
B8 |
Critical reasoning skills and ethical commitment with the society: sensitivity in front of bioethical problems and to the ones related to the natural resource conservation |
C1 |
Ability to express oneself correctly, both orally and in writing, in the official languages of the autonomous community |
C9 |
Ability to manage times and resources: developing plans, prioritizing activities, identifying critical points, establishing goals and accomplishing them. |
Learning aims |
Learning outcomes |
Study programme competences |
Capacidade de realizar análise xenéticos tanto a nivel molecular como na identificación de enfermedades xenéticas mediante estudos familiares.
Capacidade de realizar diagnóstico xenético.
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AR1 AR6 AR8 AR11 AR12
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BR1 BR3 BR5 BR6 BR8
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CC1 CC9
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Contents |
Topic |
Sub-topic |
Lecture 1. THE HUMAN GENOME: SEQUENCE AND VARIATION |
Functional elements
Protein-coding genes
Non-coding, RNA-only genes
Repetitive elements
Mitochondrial genome
Genomic variability
Epigenetics
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LECTURE 3. CHROMOSOMES AND CLINICAL SYNDROMES |
The human karyotype
Mitotic and meiotic alterations: non-disyunction
Changes in Number and structure of the chromosomes
Mosaics
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LECTURE 3. GENES AND CANCER |
Oncogenes and tumor supressor genes
Germline mutations: familiar cancer
Somatic cancer genetics
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LECTURE 4. FORENSIC GENETICS |
DNA fingerprinting |
LECTURE 5. EVOLTION OF HUMAN POPULATIONS |
Genetic diversity
Mitochondial and nuclear inheritance |
LECTURE 6. GENETIC DISEASES |
Familiar studies
Mendelian inheritance
Multiple alleles
Complex inheritance
Anticipation, expressivity, penetrance, mosaicism, mitochondrial inheritance and dynamic mutations
hEREDABILITY |
LABORATORY PRACTICES |
1- Pedigrees
2- Genetic polymorphism analyses
3- Phylogenies
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Planning |
Methodologies / tests |
Competencies |
Ordinary class hours |
Student’s personal work hours |
Total hours |
Guest lecture / keynote speech |
A6 A8 A11 A12 B1 B3 B5 B6 B8 C1 C9 |
12 |
18 |
30 |
Laboratory practice |
A1 A6 A8 B1 B3 B5 B6 B8 C1 C9 |
14 |
7 |
21 |
Mixed objective/subjective test |
B5 B1 C1 |
2 |
0 |
2 |
Practical test: |
B1 B3 B5 |
2 |
0 |
2 |
Oral presentation |
A12 A11 B1 B3 B5 |
2 |
14 |
16 |
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Personalized attention |
|
4 |
0 |
4 |
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(*)The information in the planning table is for guidance only and does not take into account the heterogeneity of the students. |
Methodologies |
Methodologies |
Description |
Guest lecture / keynote speech |
In each class, contents related to different aspects of the syllabus will be exposed. The teacher will explain the fundamental contents of each topic and indicate the activities associated with it.
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Laboratory practice |
The practical classes will consist of an explanation on the part of the professor on the conceptual bases and the objectives to reach and the development of tasks on the part of the student. It is intended that the student has maximum autonomy, facilitating means and guidance. |
Mixed objective/subjective test |
Written test in which any aspect addressed in both theoretical and practical teaching will be discussed.
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Practical test: |
A written test will be carried out to evaluate the knowledge acquired during the laboratory practices |
Oral presentation |
Students will read one or two recent articles on genetic diseases and prepare a presentation that they will defend in a time of 10-12 minutes. The consulted bibliography will be valued, synthesis capacity, oral expression and argumentation.
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Personalized attention |
Methodologies
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Practical test: |
Oral presentation |
Laboratory practice |
Guest lecture / keynote speech |
Mixed objective/subjective test |
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Description |
Students: will request tutoring and will be attended via email or TEAMS.
CONTINXENCE PLAN: in case of confinement, students will request tuition and it will be done via TEAMS or email |
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Assessment |
Methodologies
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Competencies |
Description
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Qualification
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Practical test: |
B1 B3 B5 |
The knowledge acquired during the laboratory practices will be valued. |
15 |
Oral presentation |
A12 A11 B1 B3 B5 |
Students will prepare a 10-minute presentation on a topic related to any of the content covered in the subject.
|
30 |
Laboratory practice |
A1 A6 A8 B1 B3 B5 B6 B8 C1 C9 |
It will be valued the knowledge about the meaning of the tasks carried out, and the interpretation of the results obtained. |
15 |
Mixed objective/subjective test |
B5 B1 C1 |
The domain of theoretical and practical concepts will be valued, clarity in the explanations, capacity to relate and integrate the information received treated in the magisterial sessions and in the laboratory and bioinformatics practices, and capacity to solve questions and problems. |
40 |
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Assessment comments |
<p>Laboratory practices are mandatory.<br /><br />To pass the subject, the student must obtain at least 50% of the score assigned to the mixed test and another 50% of that of the laboratory practices.<br /><br />It will be considered NOT PRESENTED when the student has not participated in more than 20% of the scheduled assessable activities. This criterion applies to the June call. In the July call, to obtain the grade NOT PRESENTED, it will be enough to not appear for the objective tests (theory and practical exams).<br /><br />For the evaluation of the July call, the student, in addition to the theory and practical exams, must present the power point presentation of the oral presentation. In the event that this activity was already evaluated in the previous call, the grade obtained will remain for July.<br /><br />For students with part-time dedication and exemption from attendance, the teacher will adopt the measures that he deems appropriate to avoid damaging her grade (flexibility in the delivery dates of the assessable activities). Instead of the oral presentation, these students will make a 2-3 page summary that must be delivered in pdf to the teacher for evaluation.</p><p>The fraudulent performance of the tests or evaluation activities will directly imply the application of the current regulations of the UDC</p>
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Sources of information |
Basic
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Pasternak, Jack (2005). An introduction to human molecular genetics. Hoboken, New Jersey. John Wiley &amp; Sons
Strachan, T. &amp; Read, A.P. (2004). Genética Molecular Humana (3ª ed). McGrawHill, México.
T Strachan, AP Read (2010). Human Molecular Genetics 4th ed.. Garland Science |
Teachers will recommend recent scientific articles to prepare and expand the content of the subject. The articles will be hosted on the Moodle platform from the beginning of the course. |
Complementary
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King, Roger (2000). Cancer biology (2º ed). Essex, UK. Pearson Education Limited
Novo Villaverde, F.J. (2007). Genética humana. Conceptos, mecanismos y aplicaciones de la Genética en el campo de la biomedicina. . Pearson, Prentice Hall. Madrid.
Jorde, L.B. Carey, J.C. &amp; White, R.L. (1996). Genética Médica.. Mosby.
Sudbery, P. 2004. (2004). Genética molecular humana. . Pearson, Prentice Hall. 2ª ed. Madrid.
Jobling, M.A.; Hurles, M.E. ; Tyler-Smith, C. (2004). Human evolutionary genetics: origins, peolples &amp; disease. New York, Garland Plublishing
Vogel, F. &amp; Motulsky, A.G. (1997). Human Genetics: Problems and Approaches (3th ed). Springer Verlag, Heidelberg, Germany
Cummings, Michael R. (2003). Human heredity: principles and issues. Pacific Grove, California. Thompson
Maroni, G. (2001). Molecular and Genetic Analysis of Human Trait.. Blackwell Science. Malden, MA, USA.
Pecornio, Lauren (2005). Molecular biology of cancer. Oxford, UK. Oxford University Press
Emery, A.E.H. &amp; Mueller, R.F. (1992). Principios de Genética Médica.. Churchill Livingstone.
McKinnell R.; Parchment, R. et al (2006). The biological basis fo cancer (2º ed). Cambridge, NY. Cambridge University Press |
O alumnado PRESENCIAL E SEMIPRESENCIAL, e recibirá por parte
dos profesores da materia webgrafía reciente e artículos de revisión
para preparar axeitadamente a materia. PLAN DE CONTIXENCIA: se aplicará o mesmo tratamento (proporcionaremos webgrafía axeitada) na plataforma Moodle. |
Recommendations |
Subjects that it is recommended to have taken before |
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Subjects that are recommended to be taken simultaneously |
Immunology/610441009 | Stem Cells and Cell Therapy/610441010 |
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Subjects that continue the syllabus |
Cellular Techniques/610441001 | Molecular Techniques/610441002 | Genetic Variation Mechanisms/610441005 |
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Other comments |
Attendance at lectures makes it possible to deal with any doubts or questions that may arise in the course of the explanations, facilitating the understanding of the subjects. Study should include regular reading of at least the recommended bibliography. Group study and work favours understanding and develops a critical spirit. The doubts and difficulties that arise in any aspect of the subject will be resolved as soon as possible, raising them in the classroom or attending individual tutorials. Given that part of the recommended bibliography for this subject is in English, it is recommended to have a good command of this language, at least at the level of comprehension of written texts. Gender Perspective In
this subject, the gender perspective will be taken into account, sexist
attitudes will not be tolerated and the values of respect and equality
will be promoted.
Program Green Campus
Empower of Sciences To help to achieve some sustainable immediate surroundings
and fulfil with the point 6 of the Environmental Statement of the faculty of
Sciences (2020), the documentary works that realise in this matter: a. They will request mostly in virtual format and computer support b. To realise in
paper: -they will not employ plastic -will realise impressions to double expensive -will employ paper
recycled -will avoid the
realisation of drafts The Environmental Statement is available in: https://ciencias.udc.es/images/Facultade/Green_Campus/Regulamento_Comit%C3%A9_Green_Campus_FCiencias.pdf |
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