Study programme competencies |
Code
|
Study programme competences / results
|
A1 |
Ability to use chemistry terminology, nomenclature, conventions and units |
A4 |
Knowledge of main types of chemical reaction and characteristics of each |
A6 |
Knowledge of chemical elements and their compounds, synthesis, structure, properties and reactivity |
A9 |
Knowledge of structural characteristics of chemical and stereochemical compounds, and basic methods of structural analysis and research |
A10 |
Knowledge of chemical kinetics, catalysis and reaction mechanisms |
A14 |
Ability to demonstrate knowledge and understanding of concepts, principles and theories in chemistry |
A15 |
Ability to recognise and analyse new problems and develop solution strategies |
A17 |
Ability to work safely in a chemistry laboratory (handling of materials, disposal of waste) |
A19 |
Ability to follow standard procedures and handle scientific equipment |
A20 |
Ability to interpret data resulting from laboratory observation and measurement |
A21 |
Understanding of qualitative and quantitative aspects of chemical problems |
A26 |
Ability to follow standard laboratory procedures in relation to analysis and synthesis of organic and inorganic systems |
B2 |
Effective problem solving |
B3 |
Application of logical, critical, creative thinking |
B4 |
Working independently on own initiative |
C1 |
Ability to express oneself accurately in the official languages of Galicia (oral and in written) |
Learning aims |
Learning outcomes |
Study programme competences / results |
Further knowledge of the most important principles of stereochemistry and conformational analysis of organic compounds |
A1 A9
|
B2
|
C1
|
Be able to predict and explain the stereochemistry evolution of chemical reactions |
A1 A9
|
|
|
Possess knowledge of the main features, the main explanatory theories and mechanisms of the main reactions of C-C bond and C-heteroatom bond formation |
A1 A4 A10 A14 A15 A21
|
B2
|
C1
|
Possess knowledge of the interconversion methods of the main functional groups |
A1 A4 A6 A14
|
B2 B3
|
|
Possess knowledge of the main objectives in organic synthesis, the main strategies of synthesis and the retrosynthetic analysis |
A1 A4 A14
|
B2
|
|
Possess knowledge of some advanced techniques in the research laboratory of Organic Chemistry |
A17 A19 A20 A26
|
B2 B3 B4
|
|
Contents |
Topic |
Sub-topic |
Chapter 1. Stereochemistry and conformational analysis |
Static and dynamic stereochemistry. Stereoselective and stereospecific chemical reactions (chemo-, regio- and stereoselective/specific reactions).
Conformational analysis: conformational effects on reactivity.
|
Chapter 2. Synthetic methods |
Protective groups. Methodology of the retrosynthetic analysis. Types of transformations. Examples |
Chapter 3. Pericyclic reactions |
Introduction: characteristics of pericyclic reactions and theoretical approaches. Electrocyclic, Cycloaddition reactions and sigmatropic rearrangements. |
Chapter 4. Generation of carbon-carbon bonds by Free-Radical reactions and carbenes.
|
Structure. Radical preparation. Radical reactions: coupling, addition, fragmentation and rearrangements. Carbens. Diazomethane. Carbene reactions. Alkene metathesis
|
Chapter 5. Generation of carbon-carbon bond by enols and enolates. |
Alkylation, acylation and conjugate addition of enols and enolates |
Chapter 6. Generation of carbon-carbon double bond
|
Wittig and Horner-Wadswoth-Emmons reactions. |
Chapter 7. Generation of carbon-carbon bond and carbon –heteroatom bonds by organometallic compounds |
Allylation of carbonyl compounds. Cross coupling reaction. Heck reaction. Carbon-heteroatom bond formation: Buchwald-Hartwig |
Chapter 8. Functional group interconversion reactions mediated by reduction and oxidation transformations. |
Functional group interconversion reactions through reduction and oxidation reactions. |
Planning |
Methodologies / tests |
Competencies / Results |
Teaching hours (in-person & virtual) |
Student’s personal work hours |
Total hours |
Introductory activities |
A14 |
1 |
0 |
1 |
Guest lecture / keynote speech |
A1 A4 A6 A9 A10 A14 |
25 |
62.5 |
87.5 |
Problem solving |
A15 A21 B2 B3 B4 C1 |
9 |
18 |
27 |
Laboratory practice |
A17 A19 A20 A26 |
10 |
15 |
25 |
Mixed objective/subjective test |
A1 A4 A6 A9 A10 A14 B2 B3 C1 |
4 |
4 |
8 |
|
Personalized attention |
|
1.5 |
0 |
1.5 |
|
(*)The information in the planning table is for guidance only and does not take into account the heterogeneity of the students. |
Methodologies |
Methodologies |
Description |
Introductory activities |
An introduction to the subject will be presented to the students where the tasks to be performed along the course and the methodologies, assessment methods and the most relevant literature will be explained. It will be held the first day. |
Guest lecture / keynote speech |
It is planned to carry out 25 sessions of lectures in one group where the theoretical contents of the subject together with relevant illustrative examples will be presented. It will consist mainly of Power Point presentations. Students will have copies of all the presentations via the Moodle application, so that students can prepare them before classes. Interactive student participation will be encouraged at all times. |
Problem solving |
It is planned to carry out 9 problem seminar sessions in small groups where students will solve the problems elaborated by the teacher. Students will have in advance notice of such problems through the Moodle application. These seminars will also be used to solve any doubts that arise during the theoretical classes |
Laboratory practice |
It is planned to carry out three experimental working sessions in which students will have to perform the experiments scheduled. The students will have the procedure and information about such experiments in advance through the Moodle application, so that they can prepare them before the start of the experiment at the laboratory. The student will have to demonstrate the know-how of the experiment before entering the laboratory. They have to elaborate a laboratory notebook which has to be given to the teacher at the end of the experimental work. |
Mixed objective/subjective test |
A final exam has to be done by the student on the dates established by the Faculty Board. Additionally, there is no mandatory midterm exam which will be eliminatory, so that students who pass this test does not need to be tested by that part at the final exam.The aim of these exams will be evaluate the knowledge and skills acquired by students. |
Personalized attention |
Methodologies
|
Laboratory practice |
|
Description |
This activity implies a personal interview to be carried out before carrying out the laboratory classes in order to establish the operations and principles required for the experimental work. |
|
Assessment |
Methodologies
|
Competencies / Results |
Description
|
Qualification
|
Problem solving |
A15 A21 B2 B3 B4 C1 |
Student attendance at these seminar classes will be evaluated and their active participation will be assessed by questioning both in the classroom and through email. They will also be evaluated in the resolution of the problems at the seminars. |
15 |
Laboratory practice |
A17 A19 A20 A26 |
Firstly, students will be evaluated through a personal interview before they start each experiment. Then the student work at the laboratory will be evaluated from the point of view of organization, management skills to handle all chemicals, equipment, and apparatus with care. Finally, the laboratory notebook that student will submit at the end of the experiments will be also evaluated. The attendance and pass these experimental classes are a necessary condition to pass this subject. Attendance at these experimental classes avoids being considered as not presented. |
15 |
Mixed objective/subjective test |
A1 A4 A6 A9 A10 A14 B2 B3 C1 |
Students will have to solve similar problems in the written exams to those done at the seminar classes. There are two exams: the first one or noncompulsory partial exam will take place in about half of semester and the final exam to be held on a fixed date on the calendar established by the Faculty Board. The partial exam is not compulsory and is eliminatory, so that students who pass it, they do not have to be evaluated from this part at the final exam. |
70 |
|
Assessment comments |
Students must attend all experimental laboratory classes in order to pass this subject. They must reach at less a 45% for each evaluation items (including both partial exams if the student does not take the global final exam) and they must reach equal to or greater than 5 points average rating. An essential requirement to pass the subject is to pass the experimental laboratory classes. A student shall be considered “not presented” when he is not attending the experimental laboratory classes and he is not present at the final exam. Students will keep the rates from experimental laboratory classes and from the seminars at the second opportunity in July. This new exam will be held on dates determined by the Faculty Board and the qualification will replace the one obtained in January. Students at the second opportunity may only be eligible for honors if the maximum number of them for this subject, according to the academic regulations, has not been covered in full at the first opportunity. The student who has not passed the laboratory practices will have to perform a test in the laboratory where he will perform the repetition of a part that will be indicated by the teacher. He must pass this test as an essential condition to pass the matter in that second opportunity. Part-time students or students with special academic permission (according to the rules of the UDC): The same evaluation criteria listed above are applied, but it´s not mandatory to attend classroom lectures. It is compulsory to attend laboratory practical sessions. Students who take the exam in the early December call will be ruled by what is established in the 2022-23 Course's Teaching Guide. If plagiarism is detected, the UDC regulations will apply.
As
stated in the different applicable regulations for university teaching, an
attempt will be made to incorporate the gender perspective in this matter. Work will be done to identify and modify prejudices
and sexist attitudes as well as situations of discrimination based on gender
and actions and measures will be proposed to correct them and promote values of
respect and equality.
|
Sources of information |
Basic
|
Carda, M., Marco, J.A., Murga, J., Falomir, E. (2010). Análisis retrosintético y síntesis orgánica. Castellón de la Plana, Universitat Jaume I
Quiroga Feijóo, M. L (2007). Estereoquímica: conceptos y aplicaciones en química orgánica. Madrid, Síntesis
Harwood, L. M.; Moody, C. J.; Percy, J. M. (1999). Experimental Organic Chemistry. Standard and microscale 2º Ed.. Oxford: Blackwell Science
Clayden, J.; Greeves, N.; Warren, S.; Wothers, P., (2012). Organic Chemistry. Oxford, University Press
McMurry, J. (2000). Química Orgánica. México. Thomsom
Ege, S. (1997). Química Orgánica: Estructura y reactividad. Barcelona. Reverté |
|
Complementary
|
Carey, F. A.; Sundberg, R. J. (2007). Advanced Organic Chemistry 5º Edición. New York: Springer
Smith, M. B.; March, J (2007). March’s Advanced Organic Chemistry 6º Ed.. New York: Wiley
Norman, R. O. C.; Coxon, J. M. (1993 (2001 imp.)). Principles of Organic Synthesis. Cheltenham (RU): Nelson Thornes
Carda, M., Rodríguez, S., González, F., Murga, J., Falomir, E., Castillo, E. (1996). Síntesis Orgánica. Resolución de problemas por el método de la desconexión. Castellón de la Plana: Universitat Jaume I
Eliel, E. L., Wilen, S.H. (1994). Stereochemistry of organic compounds. New York : John Wiley & Sons |
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Recommendations |
Subjects that it is recommended to have taken before |
Organic Chemistry 1/610G01026 | Organic Chemistry 2/610G01027 | Intermediate Organic Chemistry/610G01028 | Experimental Organic Chemistry/610G01029 | Chemistry Laboratory 2/610G01032 |
|
Subjects that are recommended to be taken simultaneously |
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Subjects that continue the syllabus |
Medicinal Chemistry/610G01040 | Final Dissertation/610G01043 |
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