| Study programme competencies |
|
Code
|
Study programme competences
|
| A1 |
Skills of using usual techniques and instruments in the cellular, biological and molecular research: that are able to use techniques and instruments as well as understanding potentials of their uses and applications. |
| A2 |
Skills of working in a sure way in the laboratories knowing operation handbooks and actions to avoid incidents of risk. |
| A4 |
Skills to apply molecular techniques to the study of the plant cell physiology, its response to external triggers and their biotechnological applications. |
| A6 |
Skills of understanding the functioning of cells through the structural organization, biochemistry, gene expression and genetic variability. |
| A7 |
Skills of knowing and analyzing specific cellular systems as stem cells, nerve cells, cells of the immune system, or other cells related to several pathologies. |
| A13 |
Skills to become a professional in health, pharmacy, veterinary, animal production, biotechnology or food sectors. |
| B1 |
Analysis skills to understand biological problems in connection with the Molecular and Cellular Biology and Genetics. |
| B2 |
Skills of decision making for the problem solving: that are able to apply theoretical knowledges and practical acquired in the formulation of biological problems and the looking for solutions. |
| B3 |
Skills of management of the information: that are able to gather and to understand relevant information and results, obtaining conclusions and to prepare reasoned reports on scientific and biotechnological questions |
| Learning aims |
| Learning outcomes |
Study programme competences |
| Perform a comprehensive reading of scientific texts related to the module materials. |
|
BR3
|
|
| Skills of critical assessment of assumptions and interpretation of results |
|
BR1
BR2
|
|
| Understanding of the structure and function of the cells from an interdisciplinary perspective on where the Cell Biology, Cytology, Genetics and Molecular Biology converge. |
AR6
AR7
|
|
|
| Understanding of the biochemical and physiological processes that allow signaling between cells and structural elements, as well as causing aspects of diseases related to alterations in cellular signalling and the tools used to study |
AR6
|
|
|
| Acquire knowledge on experimental techniques to the study of the molecular mechanisms of regulation of gene expression as well as the molecular machinery involved in these process and its systems of regulation
|
AR4
|
|
|
| Learn about the characteristics of proteins and complexes involved in the regulation of gene expression, their interaction with genetic material, and the enzymatic reactions that modulate its activity
|
AR6
|
|
|
| Acquire knowledge on experimental techniques used in the study of the molecular mechanisms involved in mammalian cell signaling
|
AR4
AR13
|
BR1
BR2
|
|
| Learn about some of the experimental techniques used to study signaling in plants
|
AR1
AR2
AR4
AR13
|
BR1
BR2
|
|
| Understanding of the processes involved in signaling during the different phases of the plant development and their response to the environment |
AR6
|
|
|
| Contents |
| Topic |
Sub-topic |
| Biochemical mechanisms of cell signaling. |
Description of the elements involved in cell signaling: signals, receptors, and signal transduction mechanisms.
|
| Examples in animal cells. |
Cell signaling in Cell cycle, Apoptosis, Cancer and Cellular Aging |
| Examples in plant cells. |
Phytohormones: Perception and Signal Transduction. Light perception and signalling in plants. The control of developmental phase transitions in plants: vegetative, reproductive and senescence phases.
|
| Laboratory practical classes |
Practical laboratory work on cell signaling |
| Planning |
| Methodologies / tests |
Competencies |
Ordinary class hours |
Student’s personal work hours |
Total hours |
| Introductory activities |
B2 |
1 |
0 |
1 |
| Guest lecture / keynote speech |
A6 A7 |
13 |
0 |
13 |
| Directed discussion |
A6 A13 B1 B3 B2 |
0 |
7 |
7 |
| Objective test |
A4 A6 A7 B1 B2 |
2 |
24 |
26 |
| Laboratory practice |
A1 A2 A4 A13 B1 B2 |
7 |
13 |
20 |
| Document analysis |
B3 |
0 |
5.5 |
5.5 |
| |
| Personalized attention |
|
2.5 |
0 |
2.5 |
| |
| (*)The information in the planning table is for guidance only and does not take into account the heterogeneity of the students. |
| Methodologies |
|
Methodologies |
Description |
| Introductory activities |
Introduction to the subject: brief description of the contents, activities and schedule of the course. |
| Guest lecture / keynote speech |
Lectures on the topics of the subject, debate and active discussion with the students on such content.Theoretical classes will be taught using presentations in Power Point or similar programs. All the material used to teach master classes will be available to students in the UDC Moodle virtual platform.
|
| Directed discussion |
Selection of topical articles related to the themes of the course. Students will have to make an oral presentation or a written report, explaining the methodology used, as well as the social and scientific impact of the research. |
| Objective test |
The exam to evaluate the level of theoretical knowledge on the topics of the subject will consist of multiple choice questions, problems, and short answer questions about the theoretical content. |
| Laboratory practice |
Carrying out, individually or in group, a small research work in the lab, related to cell signaling. Presentation of the results in a scientific paper format. |
| Document analysis |
For the preparation of the directed discussion, students should make a prior search for scientific articles in the bibliographic databases recommended by teachers. Students will select the most appropriate scientific works and they will make an analysis of the methodology and the impact of the results obtained in the society. |
| Personalized attention |
|
Methodologies
|
| Objective test |
| Laboratory practice |
| Directed discussion |
| Guest lecture / keynote speech |
| Document analysis |
|
| Description |
Students may ask for tutoring classes (previous e-mail appointment) in order to answer any questions on:
- the material taught in the course
- preparation of the issues to be addressed in the different activities
- bibliographic material and other resources that can be used to perform various activities
- the presentation of practical work
|
|
| Assessment |
|
Methodologies
|
Competencies |
Description
|
Qualification
|
| Objective test |
A4 A6 A7 B1 B2 |
Objective exam consisting of:
-multiple choice test
-short answer questions
-problems |
45 |
| Laboratory practice |
A1 A2 A4 A13 B1 B2 |
Carrying out, individually or in group, a small research work in the lab, related to cell signaling. Presentation of the results in a scientific paper format.
|
25 |
| Directed discussion |
A6 A13 B1 B3 B2 |
Selection of topical articles related to the themes of the course. Defense and discussion, with the other students and teachers, of the methodology used, and the social and scientific impact of such research. |
30 |
| |
|
Assessment comments |
STUDENTS WITH DIFFICULTIES FOR ATENDANCE. Those students who, for various reasons that may show, may not be able to attend any assessable activities, must put in contact with the teachers of the subject during the first week of the course in order to coordinate alternative activities to achieve 100% of the possible points. The students with top marks in the first evaluation period (June) will have priority to achieve MATRÍCULA DE HONOR (qualification with Honors) |
| Sources of information |
|
Basic
|
LODISH H, DARNELL J., BERK A., ZIPURSKY L., MATSUDAIRA P. y BALTIMORE D. (2002). Biología Celular y Molecular, 4ª ed. (y posteriores). Editorial Médica Panamericana. S.A.
ALBERTS B, JOHNSON J, LEWIS J, RAFF M, ROBERTS K, WALTER P (2002). Molecular Biology of the Cell 4ª ed.. Garland Publishers
|
|
INTRODUCTION TO CELLULAR SIGNALING
LODISH H, DARNELL J., BERK A., ZIPURSKY L., MATSUDAIRA P. y BALTIMORE D. Biología Celular y Molecular, 4ª ed. Editorial Médica Panamericana. S.A. (2002) y ediciones posteriores.
ALBERTS B, JOHNSON J, LEWIS J, RAFF M, ROBERTS K, WALTER P. Molecular Biology of the Cell 4ª ed. Garland Publishers (2002) y ediciones posteriores. |
|
Complementary
|
KRAUSS (2001). Biochemistry of Signal Transduction and Regulation. 2nd ed.. Wiley-VCH. Weinhein.
YANG, Z. (2008). Intracellular Signaling in Plants.. Wiley-Blackwell.
GEWIRTZ, HOLT & GRANT (2007). Apoptosis, Senescence and Cancer. 2nd ed. . Humana Press. New Jersey.
STEIN & PARDEE (2004). Cell Cycle and Growth Control. 2nd ed.. John Wiley & Sons Inc. New Jersy.
SMITH A.M., COUPLAND, G., DOLAN, L., HARBERD, N., JONES J., MARTIN, C., SABLOWSKI R. & AMEY, A. (2009). Plant Biology.. Garland Science.
TAIZ, L. & ZEIGER, E. (2010). PLant physiology, 5th edition.. Sinauer Associates.
PFANNSCHMIDT, T. (2009). Plant signal transduction. Methods and protocols.. Springer Verlag.
DEL RIO, L.A. & PUPPO, A. (2009). Reactive Oxygen Species in Plant Signaling.. Springer Verlag.
BALUSKA, F. & MANCUSO, S. (2009). Signaling in Plants.. Springer Verlag.
HELMREICH (2002). The Biochemistry of Cell Signalling. Oxford University Press Inc. New York.
WEINBERG (2007). The Biology of Cancer.. Garland Science, Taylor and Francis Group, LLC. New York.
JONES, R., OUGHAM, H., THOMAS, H. & WAALAND, S. (2013). The molecular life of plants.. Wiley-Blackwell
|
|
EXAMPLES OF SIGNALING IN MAMMALS
- HELMREICH (2002). The Biochemistry of Cell Signalling. Oxford University Press Inc. New York.
- KRAUSS (2001). Biochemistry of Signal Transduction and Regulation. 2nd ed. Wiley-VCH. Weinhein.
- STEIN & PARDEE (2004). Cell Cycle and Growth Control. 2nd ed. John Wiley & Sons Inc. New Jersy.
- GEWIRTZ, HOLT & GRANT (2007). Apoptosis, Senescence and Cancer. 2nd ed. Humana Press. New Jersey.
- WEINBERG (2007) The Biology of Cancer. Garland Science, Taylor and Francis Group, LLC. New York.
EXAMPLES OF SIGNALING IN PLANTS
- BALUSKA, F. & MANCUSO, S. 2009. Signaling in Plants. Springer Verlag.
- DEL RIO, L.A. & PUPPO, A. (2009).Reactive Oxygen Species in Plant Signaling. Springer Verlag.
- HEDDEN, P. & THOMAS, S. (2006). Plant hormone signaling. Blackwell Scientific Publishers
- PFANNSCHMIDT, T. (2009). Plant signal transduction. Methods and protocols. Springer Verlag.
- SCHEEL, D. & WASTERNACK, C. 2002. Plant signal transduction. Oxford University Press, New York.
- SMITH A.M., COUPLAND, G., DOLAN, L., HARBERD, N., JONES J., MARTIN, C., SABLOWSKI R. & AMEY, A. (2009). Plant Biology. Garland Science.
- YANG, Z. 2008. Intracellular Signaling in Plants. Wiley-Blackwell.
- Yoshioka, K. & Shinozaki, K. 2009. Signal crosstalk in plant stress responses. Wiley-Blackwell.
- Scientific review articles: in an updated way, scientific articles on the topics covered in the course will be uploaded to the virtual platform Moodle
|
| Recommendations |
| Subjects that it is recommended to have taken before |
| Stem Cells and Cell Therapy/610441009 | | Molecular Plant-Pathogen Interaction Mechanisms/610441018 |
|
| Subjects that are recommended to be taken simultaneously |
| Advanced Cellular Biology/610441003 | | Regulation of gene expression/610441006 |
|
| Subjects that continue the syllabus |
|
|