| Study programme competencies |
| Code | Study programme competences |
| A3 | Skills of understanding the functioning of cells through the structural organization, biochemistry, gene expression and genetic variability. |
| A6 | Skills of understanding the functioning of cells through the structural organization, biochemistry, gene expression and genetic variability. |
| A11 | Skills of understanding the structure, dynamics and evolution of genomes and to apply tools necessary to his study. |
| A12 | Skills to understand, detect and analyze the genetic variation, knowing genotoxicity processes and methodologies for its evaluation, as well as carrying out diagnosis and genetic risk studies. |
| A13 | Skills to become a professional in health, pharmacy, veterinary, animal production, biotechnology or food sectors. |
| B1 | Analysis skills to understand biological problems in connection with the Molecular and Cellular Biology and Genetics. |
| B2 | Skills of decision making for the problem solving: that are able to apply theoretical knowledges and practical acquired in the formulation of biological problems and the looking for solutions. |
| Learning aims | |||
| Learning outcomes | Study programme competences | ||
| Comprehensive reading of scientific texts related to the module subjects Ability to expose the current state of knowledge within this field Critical ability to evaluate hypotheses and interpret results Understanding cell structure and function from an interdisciplinary vision in which Cell Biology, classical Cytology, Genetics and Molecular Biology converge Understanding of the biochemical and physiological processes that allow signaling between cells and with structural elements, as well as the causative aspects of pathologies related to alterations in cell signaling and the tools used for your study Know the experimental techniques to access the study of the molecular mechanisms of regulation of gene expression as well as the molecular machinery involved and their regulatory systems To know the characteristics of the proteins and complexes involved in the regulation of gene expression, their interaction with genetic material and the enzymatic reactions that modulate their activity. To know the mechanisms that cause genetic variability | AR3 AR6 AR11 AR12 AR13 |
BR1 BR2 |
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| Contents |
| Topic | Sub-topic |
| Unit 1. Genetic variation: mutation |
Genetic variation and its significance. Origin and consequences of mutation. Chromosome rearrangements. Mutation rates. Reversion and supression. |
| Unit 2. Mobile DNA | Abundance in the genomes. Classification of transposable elements. Proliferation Molecular evolution. Impact on the genomes. Domestication |
| Unit 3.Genetic recombination | Recombination rates. Gene conversion. Sexual dimorphism and recombination rate, crossing-over and gene conversion. Gene conversion bias. |
| Unit 4. Evolution of scientific thought regarding the origin of genetic variability. Woese's contribution. |
Cellular evolution: the path "bumpy" to "who knows where." History of evolutionary thought. State of Microbiology (and Virology) during most of the 20th century. Carl Woese. LUCA. Generation of genetic variability in the beginning of life. |
| Unit 5. Microbial evolution in the genomics era. | The turbulent dynamics of microbial evolution. Damned concepts of classical genetics: genetic elements with a Lamarckian flavor? Evolution of Evolvability? |
| Unit 6. The mysterious world of viruses. | Are viruses alive? Evolution of viruses and viral replicons. Viral Population Dynamics Models |
| Planning | ||||
| Methodologies / tests | Competencies | Ordinary class hours | Student’s personal work hours | Total hours |
| Guest lecture / keynote speech | A6 A11 A12 A13 B1 | 10 | 20 | 30 |
| Long answer / essay questions | B2 B1 | 2 | 8 | 10 |
| Document analysis | A3 A6 A11 A12 B1 | 4 | 10 | 14 |
| Laboratory practice | A3 A11 | 10 | 10 | 20 |
| Personalized attention | 1 | 0 | 1 | |
| (*)The information in the planning table is for guidance only and does not take into account the heterogeneity of the students. | ||||
| Methodologies |
| Methodologies | Description |
| Guest lecture / keynote speech | In the case of the FULLY ATTENDING students, the contents of the program will be lectured during each master session. In the case of SEMI-ATTENDING students, the content of master sessions (exactly the same content) will be uploaded to Moodlem, either in recorded or written form. CONTINGENCY PLAN: FULLY ATTENDING students will have the same treatment as SEMI-ATTENDING students, in case of confinement. |
| Long answer / essay questions | Written test that will cover any aspect addressed in Theory and Lab classes. FULLY ATTENDING students, the test will take place in a regular classroom at the "Fcultade de Ciencias". SEMI-ATTENDING students, the written test will be done through Moodle or TEAMS, the same day and at he same time as the FULLY ATTENDING students CONTINGENCY PLAN: FULLY ATTENDING students will be treated in the same way as SEMI-ATTENDING students, in case of confinment. |
| Document analysis | FULLY ATTENDING and SEMI-ATTENDING students will read a series of research articles related to the topic. This work will be reflected in a power point preparation that will be presented and presented in the classroom (in the case of FULLY ATTENDING students), or in writing (in the case of SEMI-ATTENDING students). CONTINGENCY PLAN: FULLY ATTENDING students will have the same treatment as SEMI-ATTENDING students, in case of internment. All the works will be uploaded to the Moodle platform, after review by the teachers of the subject. |
| Laboratory practice | The laboratory practices are as follows: Practice 1: PCR amplification of DNA sequences Practice 2: electrophoresis of PCR products Practice 3: Work with bioinformatic tools for the analysis of PCR product CONTINGENCY PLAN: in case of confinement, the practices will be reconverted or replaced in computer analysis working with different genomic sequences. |
| Personalized attention |
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| Assessment | |||
| Methodologies | Competencies | Description | Qualification |
| Laboratory practice | A3 A11 | Attendance to lab sessions and execution of exercises proposed by the teacher will be graded. For the monitoring and grading of learning, students must prepare and present a practical notebook with its introduction, materials and methods, description of results and conclusions. In this activity the acquisition of competence A5 will be evaluated. | 15 |
| Document analysis | A3 A6 A11 A12 B1 | Os estudantes leerán varios artigos de investigación e realizarán unha presentación en power point de 10-12 minutos de duración | 15 |
| Long answer / essay questions | B2 B1 | Test de resposta múltiple sobre os contenidos teóricos e prácticos. Cando menos o 50% da proba será en inglés. Nesta actividade avaliarase a adquisición das competencias A5, A9, A16. | 70 |
| Assessment comments | |||
| Sources of information |
| Basic |
Gibson, G. (2009). A primer of genome science. Sinauer Associates
E.C. Friedberg et al. (2006). DNA repair and mutagenesis. Second edition. ASM Press
Weiner, M. P., Gabriel, S., and Claibo, J. (2007). Genetic variation: a laboratory manual. Cold Spring Harbor Laboratory Press
Meyers, R. A. (2007). Genomics and genetics: from molecular details to analysis and techniques. Wiley-VCH
N L Craig et al. (2002). Mobile DNA II. ASM Press |
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O alumnado PRESENCIAL E SEMIPRESENCIAL, e recibirá por parte dos profesores da materia webgrafía reciente e artículos de revisión para preparar axeitadamente a materia. PLAN DE CONTIXENCIA: se aplicará o mesmo tratamento (poporcinaremos webgrafía axeitada) na plataforma Moodle. |
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| Complementary |
R Scott Hawley, MY Walker (2003). Advanced genetic analysis. Finding meaning in a genome. . Blackwell Publishing
Hartl, D. L. (2009). Genetics: analysis of genes and genomes. Jones and Bartlett
Watson et al. (2004). Molecular Biology of the gene. Fifth edition. Pearson-Cummings
J. M. Coffin et al. (1997). Retroviruses. Cold Spring Harbor Laboratory Press |
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| Recommendations | |||
| Subjects that it is recommended to have taken before | |||
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| Subjects that are recommended to be taken simultaneously |
| Subjects that continue the syllabus |
| Other comments | |