| Study programme competencies |
| Code | Study programme competences |
| A3 | Skills of understanding the functioning of cells through the structural organization, biochemistry, gene expression and genetic variability. |
| A6 | Skills of understanding the functioning of cells through the structural organization, biochemistry, gene expression and genetic variability. |
| A11 | Skills of understanding the structure, dynamics and evolution of genomes and to apply tools necessary to his study. |
| A12 | Skills to understand, detect and analyze the genetic variation, knowing genotoxicity processes and methodologies for its evaluation, as well as carrying out diagnosis and genetic risk studies. |
| A13 | Skills to become a professional in health, pharmacy, veterinary, animal production, biotechnology or food sectors. |
| B1 | Analysis skills to understand biological problems in connection with the Molecular and Cellular Biology and Genetics. |
| B2 | Skills of decision making for the problem solving: that are able to apply theoretical knowledges and practical acquired in the formulation of biological problems and the looking for solutions. |
| B3 | Skills of management of the information: that are able to gather and to understand relevant information and results, obtaining conclusions and to prepare reasoned reports on scientific and biotechnological questions |
| B5 | Ability to draft, represent, analyze, interpret and present technical documentation and relevant data in the field of the branch of knowledge of the master's degree in the native language and at least in another International diffusion language. |
| B7 | Personal progress skills : that are able to learn from freelance way, adapting to new situations, developing necessary qualities as the creativity, skills of leadership, motivation for the excellence and the quality. |
| B9 | Skills of preparation, show and defense of a work. |
| B11 | That students know how to apply the knowledge acquired and their ability to solve problems in new or little-known environments within broader (or multidisciplinary) contexts related to their area of ??study |
| B12 | That students are able to integrate knowledge and face the complexity of formulating judgments based on information, which, being incomplete or limited, includes reflections on the social and ethical responsibilities linked to the application of their knowledge and judgments |
| B13 | That students know how to communicate their conclusions and the knowledge and ultimate reasons that support them to specialized and non-specialized audiences in a clear and unambiguous way |
| B14 | That students possess the learning skills that allow them to continue studying in a way that will be largely self-directed or autonomous |
| C1 | Ability to express oneself correctly, both orally and in writing, in the official languages of the autonomous community |
| C2 | Ability to know and use appropriately the technical terminology of the field of knowledge of the master, in the native language and in English, as a language of international diffusion in this field |
| C3 | Using ICT in working contexts and lifelong learning. |
| C4 | Acting as a respectful citizen according to democratic cultures and human rights and with a gender perspective. |
| C5 | Understanding the importanceof entrepreneurial culture and the useful means for enterprising people. |
| C8 | Valuing the importance of research, innovation and technological development for the socioeconomic and cultural progress of society. |
| Learning aims | |||
| Learning outcomes | Study programme competences | ||
| Comprehensive reading of scientific texts related to the module subjects Ability to expose the current state of knowledge within this field Critical ability to evaluate hypotheses and interpret results Understanding cell structure and function from an interdisciplinary vision in which Cell Biology, classical Cytology, Genetics and Molecular Biology converge Understanding of the biochemical and physiological processes that allow signaling between cells and with structural elements, as well as the causative aspects of pathologies related to alterations in cell signaling and the tools used for your study Know the experimental techniques to access the study of the molecular mechanisms of regulation of gene expression as well as the molecular machinery involved and their regulatory systems To know the characteristics of the proteins and complexes involved in the regulation of gene expression, their interaction with genetic material and the enzymatic reactions that modulate their activity. To know the mechanisms that cause genetic variability | AR3 AR6 AR11 AR12 AR13 |
BR1 BR2 BR3 BR5 BR7 BR9 BC2 BC3 BC4 BC5 |
CC1 CC2 CC3 CC4 CC5 CC8 |
| Contents |
| Topic | Sub-topic |
| Unit 1. Genetic variation: mutation |
Genetic variation and its significance. Origin and consequences of mutation. Chromosome rearrangements. Mutation rates. Reversion and supression. |
| Unit 2. Mobile DNA | Abundance in the genomes. Classification of transposable elements. Proliferation Molecular evolution. Impact on the genomes. Domestication |
| Unit 3.Genetic recombination | Recombination rates. Gene conversion. Sexual dimorphism and recombination rate, crossing-over and gene conversion. Gene conversion bias. |
| Unit 4. Evolution of scientific thought regarding the origin of genetic variability. Woese's contribution. |
Cellular evolution: the path "bumpy" to "who knows where." History of evolutionary thought. State of Microbiology (and Virology) during most of the 20th century. Carl Woese. LUCA. Generation of genetic variability in the beginning of life. |
| Unit 5. Microbial evolution in the genomics era. | The turbulent dynamics of microbial evolution. Damned concepts of classical genetics: genetic elements with a Lamarckian flavor? Evolution of Evolvability? |
| Unit 6. The mysterious world of viruses. | Are viruses alive? Evolution of viruses and viral replicons. Viral Population Dynamics Models |
| Planning | ||||
| Methodologies / tests | Competencies | Ordinary class hours | Student’s personal work hours | Total hours |
| Guest lecture / keynote speech | A6 A11 A12 A13 B1 B2 C2 C3 | 0 | 23 | 23 |
| Long answer / essay questions | A3 B2 C2 C3 | 2 | 11 | 13 |
| Document analysis | A6 A11 A12 A13 B1 B2 B3 B5 B7 B9 B11 B12 B13 B14 C1 C2 C4 C5 C8 | 1 | 14 | 15 |
| Laboratory practice | A3 C3 | 10 | 10 | 20 |
| Personalized attention | 4 | 0 | 4 | |
| (*)The information in the planning table is for guidance only and does not take into account the heterogeneity of the students. | ||||
| Methodologies |
| Methodologies | Description |
| Guest lecture / keynote speech | In each class the contents of the program will be exposed. The teachers' presentations will be incorporated into the Moodle platform. CONTINGENCY PLAN: the lectures will be held via TEAMS at the previously approved official hours |
| Long answer / essay questions | Written test in which any aspect addressed in the theoretical and practical teaching will be dealt with. CONTINGENCY PLAN: PRESENTIAL students will take the exam via TEAMS on the date and times previously established and approved |
| Document analysis | Students will read a series of research articles related to any aspect of the syllabus. This work will be reflected in a power point elaboration that will be presented and exhibited in the classroom. CONTINGENCY PLAN: students will present their work via TEAMS, in case of confinement. All works will be uploaded to the Moodle platform, after review by the subject teachers. |
| Laboratory practice | The laboratory practices are the following: Practice 1: PCR amplification of DNA sequences Practice 2: electrophoresis of PCR products Practice 3: Work with bioinformatics tools for the analysis of the sequences of the PCR products CONTINGENCY PLAN: in case of confinement, the practices will be reconverted or replaced in computer analysis working with different genomic sequences. |
| Personalized attention |
|
|
| Assessment | |||
| Methodologies | Competencies | Description | Qualification |
| Laboratory practice | A3 C3 | Attendance to lab sessions and execution of exercises proposed by the teacher will be graded. For the monitoring and grading of learning, students must prepare and present a practical notebook with its introduction, materials and methods, description of results and conclusions. In this activity the acquisition of competence A5 will be evaluated. | 15 |
| Document analysis | A6 A11 A12 A13 B1 B2 B3 B5 B7 B9 B11 B12 B13 B14 C1 C2 C4 C5 C8 | Os estudantes leerán varios artigos de investigación e realizarán unha presentación en power point de 10-12 minutos de duración | 15 |
| Long answer / essay questions | A3 B2 C2 C3 | Test de resposta múltiple sobre os contenidos teóricos e prácticos. Cando menos o 50% da proba será en inglés. Nesta actividade avaliarase a adquisición das competencias A5, A9, A16. | 70 |
| Assessment comments | |||
|
<p>Laboratory practices are mandatory.</p><p>To pass the subject, the student must obtain at least 50% of the score assigned to the essay / development test and another 50% of that of the laboratory practices.</p><p>It will be considered NOT PRESENTED when the student has not participated in more than 20% of the scheduled assessable activities. This criterion applies to the January call. In the July call, to obtain the grade NOT PRESENTED, it will be enough to not appear for the objective tests (theory and practical exams).</p><p>For the evaluation of the July call, the student, in addition to the corresponding exams, must present the power point presentation of the oral presentation. In the event that this activity was already evaluated in the January call, the grade obtained will remain for July.</p><p>For students with part-time dedication and exemption from attendance, the teacher will adopt the measures that he deems appropriate to avoid damaging her grade (flexibility in the delivery dates of the assessable activities). Instead of the oral presentation, these students will make a 2-3 page summary that must be delivered in pdf to the teacher for evaluation.</p><p> </p>
|
|||
| Sources of information |
| Basic |
Gibson, G. (2009). A primer of genome science. Sinauer Associates
E.C. Friedberg et al. (2006). DNA repair and mutagenesis. Second edition. ASM Press
Weiner, M. P., Gabriel, S., and Claibo, J. (2007). Genetic variation: a laboratory manual. Cold Spring Harbor Laboratory Press
Meyers, R. A. (2007). Genomics and genetics: from molecular details to analysis and techniques. Wiley-VCH
N L Craig et al. (2002). Mobile DNA II. ASM Press |
|
The students will receive from the teachers of the subject recent webgraphy and review articles to properly prepare the subject. They will be hosted (bibliography and webgraphy) on the Moodle platform. |
|
| Complementary |
R Scott Hawley, MY Walker (2003). Advanced genetic analysis. Finding meaning in a genome. . Blackwell Publishing
Hartl, D. L. (2009). Genetics: analysis of genes and genomes. Jones and Bartlett
Watson et al. (2004). Molecular Biology of the gene. Fifth edition. Pearson-Cummings
J. M. Coffin et al. (1997). Retroviruses. Cold Spring Harbor Laboratory Press |
|
|
| Recommendations | |
| Subjects that it is recommended to have taken before |
| Subjects that are recommended to be taken simultaneously |
| Subjects that continue the syllabus |
| Other comments | |
|
Attendance to the master classes enables the treatment of doubts
or questions that may arise in the course of the explanations,
facilitating the understanding of the topics. The study must contemplate
the habitual consultation of at least the recommended bibliography.
Study and group work favors understanding and develops a critical
spirit. Doubts and difficulties raised by any aspect of the subject must
be resolved as soon as possible, raising them in in-person classes
or attending individualized tutorials. Given that part of the
recommended bibliography for this subject is in English, it is advisable
to have knowledge of this language, at least at the level of
comprehension of written texts. Green Campus Program of the Faculty of Sciences: To
help achieve a sustainable environment and comply with point 6 of the
"Environmental Declaration of the Faculty of Sciences (2020)", documents requested as part of the course will be turned in electronically. If printed, plastic covers will not be used, they will be printed on both sides on recycled paper. Drafts will be avoided. |