Identifying Data

2020/21

Subject (*)

Applied Coordination Chemistry

Code

610509110

Study programme

Mestrado Universitario en Investigación Química e Química Industrial (Plan 2020)

Descriptors

Cycle

Period

Year

Type

Credits

Official Master's Degree

2nd four-month period

First

Optional

Language

Spanish

Teaching method

Face-to-face

Prerequisites

Department

Química

Coordinador

Fernandez Lopez, Alberto A.

E-mail

alberto.fernandez@udc.es

Lecturers

Fernandez Lopez, Alberto A.

Platas Iglesias, Carlos

E-mail

alberto.fernandez@udc.es

carlos.platas.iglesias@udc.es

Web

General description

Este curso enmárcase na especialidade de Química Sintética dedicado ao estudo da síntese e propiedades de diversas especies químicas. Dentro de dita especialidade escolléronse algúns tipos de compostos que, xa sexa polas súas especiais características, xa sexa polas súas aplicacións futuras, merecen un estudo detallado. Tendo isto en conta, a Química da Coordinación merece un estudo aparte, tanto polas particulares características dos compostos de coordinación como polos seus métodos de sínteses. Desde outro punto de vista, os chamados complexos preséntanse nunha variedade estrutural enorme que vai desde especies de dimensión molecular pasando por agregados supramoleculares, polímeros mono-, bi-, e tridimensionáis, ata chegar ao chamados Metal Organic Frameworks (MOFs) que forman redes tridimensionáis ordenadas. Dada esta enorme variedade estrutural, non é de sorprender que o número de propiedades e aplicacións que presentan sexa tamén diverso. Todas estas razóns xustifican a súa inclusión tanto na especialidade de Química sintética como nun Máster dedicado ao estudo da Química.

Contingency plan

1. Modificacións nos contidos
Non hai modificación nos contidos
2. Metodoloxías
*Metodoloxías docentes que se manteñen
Clase Maxistral, seminario e proba mixta.
*Metodoloxías docentes que se modifican
Non hai modificación nas metodoloxías docentes, salvo que pasarán a ser impartidas de forma sincrónica ou asincrónica utilizando a plataforma Moodle e Teams ou calquera outra que a UDC poña a disposición dos alumnos
3. Mecanismos de atención personalizada ao alumnado
Correo electrónico, a demanda do alumno.
Teams (ou outra plataforma similar), a petición do alumno
4. Modificacións na avaliación
Non hai modificacións na metodoloxía ou porcentaxe de avaliación das distintas actividades.
*Observacións de avaliación:
Caso de que as sesións maxistrais ou clases de seminario non se poidan celebrar de forma sincrónica, a asistencia e participación activa nestas actividades non será avaliada. A proba mixta levará a cabo utilizando Moodle, Teams ou calquera outra plataforma de teleformación que a UDC poña a disposición da comunidade universitaria.
5. Modificacións da bibliografía ou webgrafía
Non hai modificación.

Study programme competencies

Code	Study programme competences
A1	Define concepts, principles, theories and specialized facts of different areas of chemistry.
A2	Suggest alternatives for solving complex chemical problems related to the different areas of chemistry.
A3	Innovate in the methods of synthesis and chemical analysis related to the different areas of chemistry
A8	Analyze and use the data obtained independently in complex laboratory experiments and relating them with the chemical, physical or biological appropriate techniques, including the use of primary literature sources
B1	Possess knowledge and understanding to provide a basis or opportunity for originality in developing and / or applying ideas, often within a research context
B2	Students should apply their knowledge and ability to solve problems in new or unfamiliar environments within broader (or multidisciplinary) contexts related to their field of study.
B3	Students should be able to integrate knowledge and handle complexity, and formulate judgments based on information that was incomplete or limited, include reflecting on social and ethical responsibilities linked to the application of their knowledge and judgments.
B4	Students should be able to communicate their conclusions, and the knowledge and the reasons that support them to specialists and non-specialists in a clear and unambiguous manner
B7	Identify information from scientific literature by using appropriate channels and integrate such information to raise and contextualize a research topic
B10	Use of scientific terminology in English to explain the experimental results in the context of the chemical profession
B12	Being able to work in a team and adapt to multidisciplinary teams.
C1	CT1 - Elaborar, escribir e defender publicamente informes de carácter científico e técnico
C3	CT3 - Traballar con autonomía e eficiencia na práctica diaria da investigación ou da actividade profesional.
C4	CT4 - Apreciar o valor da calidade e mellora continua, actuando con rigor, responsabilidade e ética profesional.

Learning aims

Learning outcomes	Study programme competences
Students will be able to design new routes to prepare and isolate coordination compounds.	AC1 AC2 AC3 AC8	BC1 BC2 BC3 BC4 BC7 BC10	CC1 CC3
Students will be able to identify the chirality in mononuclear coordination complexes and identify its origin	AC1 AC2 AC3 AC8	BC1 BC2 BC3 BC7 BC10	CC4
Students will be able to describe the factors that imply activation small molecules after coordination to metal centres and their applications.	AC1 AC2 AC3 AC8	BC1 BC2 BC3 BC7 BC10 BC12

Contents

Topic	Sub-topic
Structural properties of coordination compounds. Characterization techniques	Structural properties in coordination compounds. Characterization techniques. - Spectroscopic techniques - Spectrometric techniques - Diffraction techniques - Techniques based on magnetic properties - Other techniques
Activation of small molecules by coordination compounds	Structure and bonding in dioxygen and dinitrogen complexes: bonding modes. Synthesis of dioxygen and dinitrogen complexes. Structural characterization of dioxygen and dinitrogen complexes: NMR and IR spectroscopy, mass spectrometry, single crystal X-ray diffraction. Synthetic applications of dioxygen and dinitrogen complexes. Future perspectives.
Coordination compounds with applications in medicine: therapeutic and diagnose tools	Coordination compounds with applications in medicine: therapeutic and diagnose tools - Antitumor metalodrugs. - Types of complexes according to the metal centre and the structure - Therapeutic mechanism. - Synthetic methods. Application of metal complexes as radiopharmaceuticals. - Properties and characteristics of the ligands and the radioisotope - Diagnostic, (PET, SPEC) and therapeutic techniques. Contrast agents in magnetic resonance imaging (MRI) Proton relaxation agents T1 (Gd3+, Mn2+ y Fe3+) y T2. Parameters affecting the efficiency. - Agents based on saturation transfer by chemical exchange (CEST). - Agents based on other nuclei (, 31P). - Hyperpolarization.
Coordination compounds in the design of new materials: coordination polymers and MOFs. Properties and applications.	Types of systems arising from the metal-ligand association. Isolated and extensive associations (coordination polymers and MOFs) Main structural characteristics and characterization. Synthetic strategies and general characterization techniques. Properties and applications.

Planning

Methodologies / tests	Competencies	Ordinary class hours	Student’s personal work hours	Total hours
Seminar	A1 A2 A3 B1 B2 B3 B4 B7 B10 B12 C1 C3 C4	7	21	28
Mixed objective/subjective test	A1 A2 A3 A8 B1 B10	2	18	20
Guest lecture / keynote speech	A2 A3 B3 B7 B12 C4	12	13	25

Personalized attention		2	0	2

(*)The information in the planning table is for guidance only and does not take into account the heterogeneity of the students.

Methodologies

Methodologies	Description
Seminar	Interactive sessions related to the different subjects with debates and exchange of opinions with students. Resolution of practical exercises (problems, test questions, interpretation and processing of information, evaluation of scientific publications, etc.)
Mixed objective/subjective test	Tests designed to gauge the achievement of both theoretical and practical knowledge and the acquisition of skills and attitudes.
Guest lecture / keynote speech	The lectures in which the contents of the subject will be explained with the assistance of illustrative examples. The class slides will be available, prior to the class. In some cases, if the number of students and their characteristics are adequate complementary methodologies as, for example, the case study or analyses of bibliographic sources might be used. The active participation of students will be encouraged. Attendance to lectures is not compulsory by highly advisable.

Personalized attention

Methodologies

Seminar

Mixed objective/subjective test

Description

Individual or small group tutorials designed to support the students in the learning process. The student may attend to the tutorial freely to solve any doubts related to the subject. Tutorials are particularly important to solve the proposed problems or the assigned tasks.
Students granted the “part time” condition will be given special attention through the tutorials which will be dedicated specifically to the solution of the problem sheets.

Assessment

Methodologies	Competencies	Description	Qualification
Guest lecture / keynote speech	A2 A3 B3 B7 B12 C4	Continuous assessment of students through questions made during the classes. Attendance and active participation will also be assessed	10
Seminar	A1 A2 A3 B1 B2 B3 B4 B7 B10 B12 C1 C3 C4	Resolution of problems and study cases. Attendance will also be assessed as well as the active participation to de different activities.	35
Mixed objective/subjective test	A1 A2 A3 A8 B1 B10	Mixed test exam with questions and problems related to class contents.	55

Assessment comments
The “no presentado” mark will be granted to those students who do not attend to the mixed text. Students granted the “part time student” condition will be assessed exclusively by the mixed text marks (100% of the subject mark)

Sources of information

Basic	J. Rivas Gispert (2008). Coordination Chemistry . Weinheim: Willey-VCH J. Rivas Gispert (2000). Química de Coordinación. Omega

Complementary
	- Patrick L. Holland. Metal–dioxygen and metal–dinitrogen complexes: where are the electrons? Dalton Trans. , 2010, 39 , 5415–5425. - Michael P. Shaver, Michael D. Fryzuk. Activation of Molecular Nitrogen: Coordination, Cleavage andFunctionalization of N2 Mediated By Metal Complexes. Adv. Synth. Catal.2003, 345 , 1061- 1076 - Hiromasa Tanaka, Yoshiaki Nishibayashi, and Kazunari Yoshizawa, Interplay between Theory and Experiment forAmmonia Synthesis Catalyzed by Transition Metal Complexes, Acc. Chem. Res.2016, 49, 987?995. - Serenella Medici, Massimiliano Peana,Valeria Marina Nurchi, Joanna I. Lachowicz,Guido Crisponi, Maria AntoniettaZoroddu. Noble metalsin medicine: Latest advances. CoordinationChemistry Reviews, 2015, 284, 329–350. - A. Merbach, L. Helm and E. Tóth, The Chemistry of Contrast Agents inMedical Magnetic Resonance Imaging: Second Edition , John Wiley & Sons,Chichester, 2013. - Eric W. Price and Chris Orvig. Matchingchelators to radiometals for radiopharmaceuticals. Chem. Soc. Rev., 2014, 43,260-290. - - Stuart R. Batten, Neil R. Champness, Xiao-MingChen, Javier Garcia-Martinez, Susumu Kitagawa, Lars Öhrström, MichaelO’Keeffe7, Myunghyun Paik Suh, and Jan Reedijk. Terminology of metal–organic frameworks andcoordination polymers (IUPAC Recommendations 2013) . Pure Appl. Chem., 2013, 85, 1715–1724. - - Bradley J. Holliday and Chad A. Mirkin, Strategies for the Construction of Supramolecular Compounds throughCoordination Chemistry , Angew. Chem. Int. Ed. 2001, 40, 2022-2043. - Shin-ichiroNoro, Hitoshi Miyasaka, Susumu Kitagawa, Tatsuo Wada,Takashi Okubo, MasahiroYamashita, and Tadaoki Mitani. FrameworkControl by a Metalloligand Having Multicoordination Ability: New SyntheticApproach for Crystal Structures and Magnetic Properties . Inorg.Chem. 2005, 44, 133-146.

Recommendations

Subjects that it is recommended to have taken before

Advanced Structural Determination/610509103

Subjects that are recommended to be taken simultaneously

Subjects that continue the syllabus

Other comments
The student must know the basic principles of coordination chemistry&nbsp;as, for example, the definition of coordination compound and its components, as well as the bonding theories used to describe this type of compounds

(*)The teaching guide is the document in which the URV publishes the information about all its courses. It is a public document and cannot be modified. Only in exceptional cases can it be revised by the competent agent or duly revised so that it is in line with current legislation.