Identifying Data

2020/21

Subject (*)

Validation of Analytical Methodology

Code

610509301

Study programme

Mestrado Universitario en Investigación Química e Química Industrial (Plan 2020)

Descriptors

Cycle

Period

Year

Type

Credits

Official Master's Degree

1st four-month period

First

Obligatory

Language

Spanish

Teaching method

Face-to-face

Prerequisites

Department

Química

Coordinador

Muniategui Lorenzo, Soledad

E-mail

soledad.muniategui@udc.es

Lecturers

Carlosena Zubieta, Alatzne

Muniategui Lorenzo, Soledad

E-mail

alatzne.carlosena@udc.es

soledad.muniategui@udc.es

Web

General description

Esta materia, de carácter obrigatorio, pertence ao Módulo M1 (Formación Obrigatoria Química Avanzada) e se relaciona coas materias do seu mesmo módulo e coas optativas da especialidade Módulo M6 (Técnicas Analíticas Avanzadas).
O seu obxetivo é capacitar ao alumno para a axeitada selección da metodoloxía analítica en función da súa aplicabilidade e a selección, cálculo e avaliación dos criterios adecuados para o fin proposto nos laboratorios de control e da industria.

Contingency plan

1. Modificacións nos contidos
Non realizaranse cambios

2. Metodoloxías
* Metodoloxías docentes que se manteñen
Seminarios, Traballos tutelados, Proba mixta, Atención personalizada.

* Metodoloxías docentes que se modifican

Prácticas de laboratorio: ao non poder realizarse de forma presencial incorporaranse os seus contidos na metodoloxía de traballo tutelado.

3. Mecanismos de atención personalizada ao alumnado

- Correo electrónico: Diariamente. De uso para facer consultas, solicitar algún encontro virtual para resolver dúbidas e facer seguimento do caso práctico e traballos tutelados.

– Moodle: Diariamente. Segundo a necesidade do alumnado. Dispón de “foros temáticos” para formular as consultas necesarias.

– Teams: sesións en grupo grande para o avance dos contidos teóricos e dos seminarios, na franxa horaria asignada á materia. Sesións en grupo pequeno para o seguimento e apoio do estudo e actividades programadas relacionadas cos seminarios e traballos tutelados.

4. Modificacións na avaliación

- A porcentaxe da avaliación das prácticas incorpórase na ponderación do traballo tutelado, o cal terá un peso del 25% da calificación da materia.

Observacións de avaliación:
- Mantéñense o resto de metodoloxías da guía docente, salvo que todas realizaríanse de forma virtual ou telemática (vía Moodle e/ou Teams).

5. Modificacións da bibliografía ou webgrafía.
Non se realizarán cambios. Xa dispoñen de todos os materiais de traballo dá maneira dixitalizada en Moodle.

Study programme competencies

Code	Study programme competences
A3	Innovate in the methods of synthesis and chemical analysis related to the different areas of chemistry
A5	Properly assess risks and environmental and socioeconomic impacts associated with special chemicals
A6	Design processes involving the treatment or disposal of hazardous chemicals
A7	Operate with advanced instrumentation for chemical analysis and structural determination.
A8	Analyze and use the data obtained independently in complex laboratory experiments and relating them with the chemical, physical or biological appropriate techniques, including the use of primary literature sources
B2	Students should apply their knowledge and ability to solve problems in new or unfamiliar environments within broader (or multidisciplinary) contexts related to their field of study.
B3	Students should be able to integrate knowledge and handle complexity, and formulate judgments based on information that was incomplete or limited, include reflecting on social and ethical responsibilities linked to the application of their knowledge and judgments.
B5	Students must possess learning skills to allow them to continue studying in a way that will have to be largely self-directed or autonomous.
B10	Use of scientific terminology in English to explain the experimental results in the context of the chemical profession
B11	Apply correctly the new technologies to gather and organize the information to solve problems in the professional activity.
B12	Being able to work in a team and adapt to multidisciplinary teams.
C1	CT1 - Elaborar, escribir e defender publicamente informes de carácter científico e técnico
C2	CT2 - Traballar en equipo e adaptarse a equipos multidisciplinares.
C3	CT3 - Traballar con autonomía e eficiencia na práctica diaria da investigación ou da actividade profesional.
C4	CT4 - Apreciar o valor da calidade e mellora continua, actuando con rigor, responsabilidade e ética profesional.

Learning aims

Learning outcomes	Study programme competences
The student must acquire knowledge about the selection of the best analysis procedure to solve problems of interest, as well as how to implement and validate this procedure.	AC8	BC2 BC5 BC11	CC1 CC2 CC3
The student must know how to select for each particular situation innovative techniques both in the treatment of the analytical sample and in the determination techniques and data processing procedures.	AC3	BC10 BC11 BC12	CC1 CC3 CC4
The student must be able to apply the knowledge acquired to the resolution of practical cases of clinical, industrial and environmental interest, among others	AC3 AC5 AC6 AC7 AC8	BC2 BC3 BC5 BC11	CC1 CC2 CC3

Contents

Topic	Sub-topic
1. Introduction: Selection of the analytical methodology	Criteria for selecting a method of analysis. Classification of methods of analysis. Characteristics of qualitative and quantitative analysis
2. Validation of analytical methodology	Selection of performance criteria for a method. Development, evaluation and use of an analytical methodology. Official guidelines for the validation of an analytical method. Validation tools. Types of intra-laboratory or inter-laboratory validation. Evaluation of validation studies
3. Innovative technologies in Analytical Chemistry	Innovative Technologies in Analytical Chemistry. Automation and miniaturization in Analytical Chemistry
Practice cases study	Practical examples will be addressed, learning how to determine the optimum operational conditions of a process, that a method is fit for purpose, ensuring that the results obtained through a methodology are reliable and of good quality, etc.

Planning

Methodologies / tests	Competencies	Ordinary class hours	Student’s personal work hours	Total hours
Guest lecture / keynote speech	A3 A5 B2 B3 B5 B11 C3 C4	10	10	20
Seminar	A8 B2 B3 B5 B10 C1 C2 C4	7	21	28
Laboratory practice	A6 A7 A8 B2 B3 B12 C2	5	5	10
Supervised projects	A8 A5 B2 B3 B5 B10 B11 B12 C1 C2 C4	3	12	15
Mixed objective/subjective test	A5 B2 B3 B10 C1 C4	2	0	2

Personalized attention		0		0

(*)The information in the planning table is for guidance only and does not take into account the heterogeneity of the students.

Methodologies

Methodologies	Description
Guest lecture / keynote speech	The teacher teaches the fundamental concepts and the most important contents of each programme topic. In addition, he/she proposes different questions to be discussed and resolved by the students, encouraging participation.
Seminar	The professor, in the seminars, clarifies and expands on some aspects dealt with in the guest lectures and laboratory practices, especially related to the practical application of the methodologies studied. Students participate and discuss possible strategies to solve environmental and/or industrial problems that arise under the guidance of the professor.
Laboratory practice	In the laboratory sessions the student will have the opportunity to make contact with advanced scientific techniques and instrumentation. Whenever possible, laboratories of research centres or companies will be visited.
Supervised projects	It will include the search for information in different sources, the elaboration, exposition and defense of a subject proposed by the teacher related to some environmental, industrial, clinical problem, etc. The hours will be dedicated to the orientation for the elaboration and exposition/defense of the same.
Mixed objective/subjective test	Final exam to evaluate the degree of learning of both theoretical and practical contents of the whole subject.

Personalized attention

Methodologies

Supervised projects

Guest lecture / keynote speech

Seminar

Laboratory practice

Description

Throughout the course, at the time specified by the teacher, all the aspects related to the teaching that the student considers necessary at each moment will be oriented and/or discussed.
In the seminars the teacher supervises for each student the methodology applied and the process of solving the problems proposed, solving individually the doubts formulated by the student and guiding the learning process.
In the supervised work it is important to carry out a personalised follow-up to comment on the progress made and to provide the student with the necessary guidance to develop the work.

The student with recognition of part-time dedication and academic exemption from attendance will be attended to in the form of tutorial hours (by appointment).

Assessment

Methodologies	Competencies	Description	Qualification
Supervised projects	A8 A5 B2 B3 B5 B10 B11 B12 C1 C2 C4	Supervised projects will be evaluated by the performance and/or presentation of the project by the students.	20
Guest lecture / keynote speech	A3 A5 B2 B3 B5 B11 C3 C4	Attendance at the teaching sessions and active participation of the student will be evaluated	5
Seminar	A8 B2 B3 B5 B10 C1 C2 C4	The seminars will evaluate the students' acquisition of knowledge and skills through problem solving, case studies, etc.	10
Mixed objective/subjective test	A5 B2 B3 B10 C1 C4	The final exam will cover all the contents of the subject. It will consist of theoretical questions, applied issues and problem solving.	60
Laboratory practice	A6 A7 A8 B2 B3 B12 C2	The work and participation of students in the practical sessions will be continuously evaluated by means of questions and oral questions, tests, etc.	5

Assessment comments
The evaluation of this subject will be done through continuous assessment and a final exam, which can only be taken by the student who participates in a minimum of 80% of the mandatory classroom teaching activities (lectures, seminars, practices). The student will have the qualification of Not Presented when he/she does not carry out the supervised work and does not take the final exam. The qualification of the assessable activities can be kept in the July call, except for the mixed test in case of being suspended. In the following academic years, the teaching-learning process, including all assessable activities, will begin again with a new course. For part-time students with academic exemption from attendance, if they are unable to take all the continuous assessment tests, the teacher will take the appropriate measures so as not to affect their grade.

Sources of information

Basic	Eurolab España. P.P. Morillas y colaboradores. (2016). Guía Eurachem: La adecuación al uso de los métodos analíticos – Una Guía de laboratorio para la validación de métodos y temas relacionados . Disponible en www.eurachem.org AOAC, IUPAC (2016). AOAC and IUPAC Official Guidelines for Validation of Analytical methods . M. VALCARCEL (1999). Principios de Química Analítica. Springer, Barcelona R. Kellner, J. M. Mermet, M. Otto, M. Valcarcel y H. M. Widmer, Eds (2004). “Analytical Chemistry: A Modern Approach to Analytical Science. Ed. Wiley-VCH.

Complementary	Compañó Beltrán R., Rios Castro A (2002). Garantía de calidad en los laboratorios analíticos. Ed. Springer. Ramis Ramos G., García Álvarez-Coque M.C (2001). Quimiometría . Síntesis. Madrid. Kruve A. et al. (2015). Tutorial review on validation of liquid chromatography–mass spectrometry methods: Part I. Analytica Chimica Acta 870 (2015) 29–44 I. Rodríguez, E. Trullos, X. Rius (2003). Validación de Métodos Analíticos Cualitativos.. Técnicas de Laboratorio, 281 (2003) 328-335. http:/www.quimica.urv.es/quimio

Recommendations

Subjects that it is recommended to have taken before

Subjects that are recommended to be taken simultaneously

Subjects that continue the syllabus

Chromatography and Analytical Separation Techniques /610509125

Advanced Atomic Techniques and Sensors/610509127

Advanced Sample Preparation Techniques/610509324

Other comments

(*)The teaching guide is the document in which the URV publishes the information about all its courses. It is a public document and cannot be modified. Only in exceptional cases can it be revised by the competent agent or duly revised so that it is in line with current legislation.