The assistance to the lectures, seminars and practicals is mandatory.
A student can obtain the qualification of "Not presented" if do not realise activities with an upper computation to 50% in the evaluation or not to present to the mixed test.
The students will have two opportunities, and those that do not surpass the subject in the first opportunity will conserve the qualification obtained in the seminars and laboratory practicals, and will realise a second mixed test in the determinate dates by the calendar fixed by the Board of Faculty. The students that are evaluated in the second opportunity only will be able to opt to the "matrícula de honor" (highest qualification) if these have not been covered at the first opportunity.

Part-time students or students with special academic permission (according to the rules of the UDC):

The
same evaluation criteria listed above would be applied, but being not
mandatory to attend classroom lectures and seminars.

Nevertheless, It is compulsory to attend practical sessions, but itwill be tried to fit the dates to the student's availability. When not possible otherwise, these students should exchange the practical activities by tasks related that
not require attendance.

The
final grade will be the sum of 20% of the mark obtained in the lab practice and 80% of the mark obtained in the mixed test. The
same criteria will be applied to both opportunities.

Students who has not attended the final exam will be assessed as "non attendance".

For all the students, the education-learning process, included the evaluation, refers to an academic course and starts every new academic course, including all the activities and procedures of evaluation programed.

Learning outcomes	Study programme competences
Know the structure and mode of action of drugs and the relationship with biological activity	A1 A9 A10 A13 A14 A15 A16 A21 A24 A25	B1 B2 B3 B4 B6 B7	C1 C2 C3 C4 C6 C7 C8
Know basic principles and strategies used to design and synthesized drugs.	A1 A9 A10 A13 A14 A15 A16 A17 A18 A19 A20 A21 A22 A23 A24 A25 A26	B1 B2 B3 B4 B6 B7	C1 C2 C3 C4 C6 C7 C8
Know the impact of drugs and the pharmaceutical companies in the society.	A13 A14 A16 A24 A25	B1 B3 B4 B6 B7	C1 C3 C6 C7 C8
The students should be able to identify apropriate information on the scientific literature, assess their responsibility in the management of information and knowledge in the field of Industrial Chemistry and the Chemical Research, use scientific terminology and appreciate the value of quality and continuous improvement	A14 A15 A16 A22 A24 A25	B1 B2 B3 B4 B6	C1 C2 C3 C4 C6 C7 C8

Topic	Sub-topic
Chapter 1. Basic principles in Medicinal Chemistry	1.1 Medicinal Chemistry : definition and basic concepts 1.2 Historical Perspective . 1.3 Pharmacokinetics and Pharmacodynamics 1.4 Drug Discovery 1.5 Drugs: nomenclature and classification
Chapter 2. Molecular basis on pharmacological activity: Pharmacodynamics	2.1 Drug-receptor interactions . Molecular topology and biological activity 2.2 Proteins: structure and function. Protein Interactions 2.3 Enzymes: enzymatic catalysis. Michaelis - Menten equation . Enzyme inhibition : Types 2.5 Cell receptors: structure and classification . 2.6 Nucleic Acids . Structure and functions. Drug interactions with nucleic acids 2.7 Interactions with lipid and carbohydrate
Chapter 3. Phramacokinetics	3.1 ADME processes. 3.2 Absorption of drugs. Modes of administration . Physicochemical properties of drugs : Lipinsky rules . Bioavailability . 3.3 Distribution of drugs. Blood : composition and properties. Removal rate . Mid life. Volume of distribution 3.4 Drug metabolism : metabolism in phase I and phase II 3.5 Elimination of drugs.
Chapter 5. Drug discovery	4.1 Steps in drug discovery. Biological target vs Phenotypic approach. Structural diversity. Chemical space. Drug binding energy. High Throughput Screening ( HTS ). Chemical libraries: combinatorial chemistry , parallel synthesis , solid phase synthesis 4.2 Strategies in drug discovery (lead discovery) . Screening modes . Drug screening methods . Drug Design 4.3 Optimization of drugs (lead optimization) . Structure- actividadIdentificación pharmacophore . Pharmacomodulation : modification of functional groups. Optimization receptor binding and pharmacokinetics .

Methodologies / tests	Competencies	Ordinary class hours	Student’s personal work hours	Total hours
Guest lecture / keynote speech	A1 A9 A10 A13 A14 A15 A16 A21 A24 A25 B1 B2 B3 B4 B6 B7 C1 C3 C4 C6 C7 C8	16	16	32
Seminar	A1 A9 A10 A13 A14 A15 A16 A21 A24 A25 B1 B2 B3 B4 B6 B7 C1 C3 C4 C6 C7 C8	7	28	35
Laboratory practice	A9 A13 A14 A15 A16 A17 A18 A19 A20 A22 A23 A25 A26 B1 B2 B3 B4 B6 B7 C1 C2 C3 C4 C6 C7 C8	10	10.5	20.5
Mixed objective/subjective test	A1 A9 A13 A14 A15 B2 B3 B6 C1 C6	4	20	24

Personalized attention		1	0	1

(*)The information in the planning table is for guidance only and does not take into account the heterogeneity of the students.

Methodologies	Description
Guest lecture / keynote speech	The contents will be presented. During the presentations the teacher can provide supplementary material to the literature with the aim that the explanations can be tracked effectively. The ability to create notes and search for information will also be developed.
Seminar	The contents of each chapter will be discussed in seminars by solving exercises and analysis of practical cases. Students will have early enough problem sets through the Moodle platform. We may request delivery of solved exercises.
Laboratory practice	Practices involving the use of software and web resources for the rational design of drugs.
Mixed objective/subjective test	A test with questions related to the contents of the subject will be asked.

Methodologies	Competencies	Description	Qualification
Mixed objective/subjective test	A1 A9 A13 A14 A15 B2 B3 B6 C1 C6	The responses in the written exam will be evaluated.	60
Guest lecture / keynote speech	A1 A9 A10 A13 A14 A15 A16 A21 A24 A25 B1 B2 B3 B4 B6 B7 C1 C3 C4 C6 C7 C8	Attendance and participation in class will be assessed	5
Laboratory practice	A9 A13 A14 A15 A16 A17 A18 A19 A20 A22 A23 A25 A26 B1 B2 B3 B4 B6 B7 C1 C2 C3 C4 C6 C7 C8	Attendance and the final report will be assessed.	20
Seminar	A1 A9 A10 A13 A14 A15 A16 A21 A24 A25 B1 B2 B3 B4 B6 B7 C1 C3 C4 C6 C7 C8	The active participation of students in solving the problems of the bulletins and assignment submitted will be assessed.	15

Assessment comments
The assistance to the lectures, seminars and practicals is mandatory. A student can obtain the qualification of "Not presented" if do not realise activities with an upper computation to 50% in the evaluation or not to present to the mixed test. The students will have two opportunities, and those that do not surpass the subject in the first opportunity will conserve the qualification obtained in the seminars and laboratory practicals, and will realise a second mixed test in the determinate dates by the calendar fixed by the Board of Faculty. The students that are evaluated in the second opportunity only will be able to opt to the "matrícula de honor" (highest qualification) if these have not been covered at the first opportunity. Part-time students or students with special academic permission (according to the rules of the UDC): The same evaluation criteria listed above would be applied, but being not mandatory to attend classroom lectures and seminars. Nevertheless, It is compulsory to attend practical sessions, but itwill be tried to fit the dates to the student's availability. When not possible otherwise, these students should exchange the practical activities by tasks related that not require attendance. The final grade will be the sum of 20% of the mark obtained in the lab practice and 80% of the mark obtained in the mixed test. The same criteria will be applied to both opportunities. Students who has not attended the final exam will be assessed as "non attendance". For all the students, the education-learning process, included the evaluation, refers to an academic course and starts every new academic course, including all the activities and procedures of evaluation programed.

Basic	Patrick, G. L (2013). An Introduction to Medicinal Chemistry. 5th ed.. New York: Oxford University Press Avendaño, C (2001). Introducción a la Química Farmacéutica. Madrid: McGraw-Hill Delgado, A.; Minguillón, C.; Joglar, J. (2003). Introducción a la Química Terapéutica. Madrid: Díaz de Santos Delgado, A.; Minguillón, C.; Joglar, J. (2002). Introducción a la síntesis de fármacos. Madrid: Síntesis Stevens, E. (2014). Medicinal Chemistry, an Introduction.. Pearson Education. New York. Thomas, Gareth (2007). Medicinal Chemistry: An introduction. Wiley

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