Identifying Data

2019/20

Subject (*)

Cytogenetics

Code

610G02022

Study programme

Grao en Bioloxía

Descriptors

Cycle

Period

Year

Type

Credits

Graduate

1st four-month period

Fourth

Optional

Language

Spanish

Teaching method

Face-to-face

Prerequisites

Department

Bioloxía

Coordinador

Mendez Felpeto, Josefina

E-mail

josefina.mendez@udc.es

Lecturers

Martinez Martinez, M. Luisa

Mendez Felpeto, Josefina

E-mail

m.l.martinez@udc.es

josefina.mendez@udc.es

Web

http://www.udc.es/grupos/xenomar

General description

Tratase dunha materia optativa centrada no estudo do cromosoma eucariota dende o punto de vista estructural, funcional e da evolución . Esta materia pretende mellorar os coñecementos adquiridos nas materias previas de Xenética e Xenética Molecular. Farase especial énfasis na organización do material xenético así como as suas implicacions na evolución dos xenomas, sua variación e manipulación.

Study programme competencies

Code	Study programme competences
A1	Recoñecer distintos niveis de organización nos sistemas vivos.
A2	Identificar organismos.
A11	Identificar e analizar material de orixe biolóxica e as súas anomalías.
A16	Realizar cultivos celulares e de tecidos.
A26	Deseñar experimentos, obter información e interpretar os resultados.
A29	Impartir coñecementos de Bioloxía.
A30	Manexar adecuadamente instrumentación científica.
A31	Desenvolverse con seguridade nun laboratorio.
B1	Aprender a aprender.
B2	Resolver problemas de forma efectiva.
B3	Aplicar un pensamento crítico, lóxico e creativo.
B5	Traballar en colaboración.
B6	Organizar e planificar o traballo.
B8	Sintetizar a información.
B9	Formarse unha opinión propia.
B10	Exercer a crítica científica.
B11	Debater en público.

Learning aims

Learning outcomes	Study programme competences
Deepen your knowledge of the organization of hereditary material with an evolutionary approach through the study of chromosomes and their variations.	A1 A16 A26 A30 A31	B1 B2 B3 B5 B6 B8 B9 B10 B11
To understand the fundamentals involve when learning about chromosome and familiar with the basic methodology employed for the study of chromosomes. Tools for cytogenetics.	A1 A2 A11 A16 A30 A31	B1 B2 B3 B5 B6 B11
Search and use of different literature and databases that allow carrying out the scientific approach to a topic related to chromosomes sources, organization, function and evolution. Management information sources of interest in cytogenetics.	A29	B3 B8 B9 B10

Contents

Topic	Sub-topic
Block 1.- Structural and Organization Genomes	1.-Organization of genomes from viruses to eukaryotes. Evolutionary aspects. 2.-The chromosomes are chromatin 3.-Levels of organization 4 - Structure of metaphase chromosomes 5.-Induced chromosome structure: Bands vs isocoras. 6.-Linkage and mapping
Block 2.- Chromosomes, celular reproduction and function	1.-Control of the cell cycle. Cycle disorders 2 - Evolution of the mitotic mechanism 3.-replication and chromosomal regions 4.-Evolution of meiosis and its genetic consequences. Meaning of sexual reproduction. 5 - Different karyotypes and their use 6.-Chromosomes and gene function
Block 3.-Chromosome variation and evolution	1.-Chromosomal rearrangements and their significance in evolution. 2.-Genetic consequences of numerical and structural variations . 3.- Chromosomal polymorphisms: evolutionary aspects.

Planning

Methodologies / tests	Competencies	Ordinary class hours	Student’s personal work hours	Total hours
Collaborative learning	A1 A2 A11 A16 A30 A31 B1 B2 B3 B5 B6 B11	28	56	84
Oral presentation	B5 B6 B8 B9 B10 B11	12	0	12
Objective test	A1 A16 B3 B8 B9 B10	2	25	27
Guest lecture / keynote speech	A26 A29 B1 B8 B11	8	0	8
Laboratory practice	A11 A16 A26 A29 A30 A31 B1 B5	15	0	15

Personalized attention		4	0	4

(*)The information in the planning table is for guidance only and does not take into account the heterogeneity of the students.

Methodologies

Methodologies	Description
Collaborative learning	Students work in groups of 2 or 3 and work collaboratively to effectively solve an assigned topic each block. They should learn to arrange and organize work among them. Perform appropriate to the subject under study literature searches . It is a mandatory activity
Oral presentation	The collaborative work by the group, will be presented orally at the end of each block. Throughout the course there will be at least three oral presentations for each student. It will consist of transmitting the rest of the seminar co-dossier prepared by the gruo (2-3 students) together. Each team member will present a part of the joint seminar, trying to fit it in coordination with their peers. It is a mandatory activity.
Objective test	Students will perform a final test consisting of different short questions that reflect different aspects learned throughout the course It is mandatory activity.
Guest lecture / keynote speech	The teacher explains the fundamental contents of each thematic block and identifies the associated activities. Attendance at these lectures and interactive sessions will be positively evaluated. The assitance will be assessed.
Laboratory practice	Laboratory practices related to the development of chromosomes and karyotypes were developed. It will be know the cell cultures, making the karyotype and develop some method of chromosome banding.

Personalized attention

Methodologies

Laboratory practice

Collaborative learning

Description

Throughout the course, the teacher will be available during the hours of interactive lectures, group tutorials / small group and individual tutoring for answering questions, guiding the development of seminars / group work and all matters related to the organization of matter.

Assessment

Methodologies	Competencies	Description	Qualification
Guest lecture / keynote speech	A26 A29 B1 B8 B11	In the keynote session, the teacher will explain the fundamental contents of each thematic block of matter. Attendance at these classes enables the treatment of questions and issues that may arise and further clarifies and organizes collaborative work group will be further developed and that will be lectures on oral presentations. Assisting them continuously is recommended.	10
Objective test	A1 A16 B3 B8 B9 B10	The final test will take place on the field marked by the Faculty. Consist of a few short questions about the novel contributions learned in the course ideas and reflection of learning as well as the realization in the responses, personal opinions and scientific literature specific answers to questions will be assessed.	40
Oral presentation	B5 B6 B8 B9 B10 B11	Clarity and precision in the presentation will be assessed. Suitable and current content. Synthesis capacity, motivation and debate. Both the submitted writen report and oral presentation will contribute to the assessment.	20
Laboratory practice	A11 A16 A26 A29 A30 A31 B1 B5	Take into account the interest to learn techniques on chromosomes, skill in the laboratory experiments ability to solve chromosomes and the attitude and ability to function in the laboratory.	10
Collaborative learning	A1 A2 A11 A16 A30 A31 B1 B2 B3 B5 B6 B11	Students will form working groups and the way teamwork is valued, how they solve the problems, the strategy when conducting literature searches to resolve the issue raised and its ability to incorporate new knowledge acquired in years above. Group work and coordination are essential in this regard. Their aptitude and attitude will be assessed throughout the course.	20

Assessment comments
The final test and practical clases are essential and mandatory activity. In the case of justified exceptional circumstances, additional measures may be taken so that the student can pass the subject, such as flexibility in the delivery date of supervised projects, flexibility in practice schedules or a global assessment test of the learning results.

Sources of information

Basic
	- Brown T.A. Genetics: A molecular approach (third edition). Chapman & Hall 1998 -Brown, T.A. Genomas (Tercera edición). Editorial Médica Panamericana S.A. 2008 -The evolution of te genomes. Edited by T.Ryan Gregory. Elsevier Academic Press. 2005 -Lacadena, J.R. Citogenética Editorial Complutense S.A. 1996 - Lewin, B. Genes IX. McGrawHill Education 2008 -Lima de Faria, A. One hundred years of chromosome research and what remains to be learned. Kluwer Academic Publishers 2003 - Lynch M. The origins of genome architecture Sinauer Associates, Inc Publishers. 2007 -Macgregor, H.C. An Introduction to Animal Cytogenetics. Chapman & Hall 1993 -Macgregor, H. & Varley, J. Working with Animal Chromosomes (second edition) John Wiley & Sons. Toronto 1988 -Wagner R.P.; Maguire M.P. & Stalling R.L. Editorial Wiley-Liss 1993
Complementary
	En primer lugar, los alumnos consultarán los libros recomendados en las materias de Genética y Genética Molecular para recordar los contenidos y conocimientos adquiridos previamente. A continuación realizarán una búsqueda bibliográfica específica en libros, artículos de revisión, publicaciones específicas que permitan incrementar el aprendizaje de la materia, teniendo como eje fundamental el cromosoma mitótico. La realización de una buena búsqueda bibliográfica estará presente en todas las valoraciones de las actividades propuestas.

Recommendations

Subjects that it is recommended to have taken before

Biology: Basic Levels of Organisation of Life I (Cells)/610G02007

Genetics/610G02019

Molecular Genetics/610G02020

Subjects that are recommended to be taken simultaneously

Subjects that continue the syllabus

Other comments

(*)The teaching guide is the document in which the URV publishes the information about all its courses. It is a public document and cannot be modified. Only in exceptional cases can it be revised by the competent agent or duly revised so that it is in line with current legislation.