| Study programme competencies |
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Code
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Study programme competences
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| A1 |
CE1 - Comprender los conceptos, principios, teorías y hechos fundamentales relacionados con la Nanociencia y Nanotecnología. |
| A2 |
CE2 - Aplicar los conceptos, principios, teorías y hechos fundamentales relacionados con la Nanociencia y Nanotecnología a la resolución de problemas de naturaleza cuantitativa o cualitativa. |
| A3 |
CE3 - Reconocer y analizar problemas físicos, químicos, matemáticos, biológicos en el ámbito de la Nanociencia y Nanotecnología, así como plantear respuestas o trabajos adecuados para su resolución, incluyendo el uso de fuentes bibliográficas. |
| A5 |
CE5 - Conocer los rasgos estructurales de los nanomateriales, incluyendo las principales técnicas para su identificación y caracterización |
| A7 |
CE7 - Interpretar los datos obtenidos mediante medidas experimentales y simulaciones, incluyendo el uso de herramientas informáticas, identificar su significado y relacionarlos con las teorías químicas, físicas o biológicas apropiadas. |
| A10 |
CE10 - Comprender la legislación en el ámbito del conocimiento y la aplicación de la Nanociencia y Nanotecnología. Aplicar principios éticos en este marco. |
| B1 |
CB1 - Que los estudiantes hayan demostrado poseer y comprender conocimientos en un área de estudio que parte de la base de la educación secundaria general, y se suele encontrar a un nivel que, si bien se apoya en libros de texto avanzados, incluye también algunos aspectos que implican conocimientos procedentes de la vanguardia de su campo de estudio |
| B2 |
CB2 - Que los estudiantes sepan aplicar sus conocimientos a su trabajo o vocación de una forma profesional y posean las competencias que suelen demostrarse por medio de la elaboración y defensa de argumentos y la resolución de problemas dentro de su área de estudio |
| B3 |
CB3 - Que los estudiantes tengan la capacidad de reunir e interpretar datos relevantes (normalmente dentro de su área de estudio) para emitir juicios que incluyan una reflexión sobre temas relevantes de índole social, científica o ética |
| B4 |
CB4 - Que los estudiantes puedan transmitir información, ideas, problemas y soluciones a un público tanto especializado como no especializado |
| B5 |
CB5 - Que los estudiantes hayan desarrollado aquellas habilidades de aprendizaje necesarias para emprender estudios posteriores con un alto grado de autonomía |
| B6 |
CG1 - Aprender a aprender |
| B7 |
CG2 - Resolver problemas de forma efectiva. |
| B8 |
CG3 - Aplicar un pensamiento crítico, lógico y creativo. |
| B9 |
CG4 - Trabajar de forma autónoma con iniciativa. |
| B10 |
CG5 - Trabajar de forma colaborativa. |
| B11 |
CG6 - Comportarse con ética y responsabilidad social como ciudadano/a y como profesional. |
| B12 |
CG7 - Comunicarse de manera efectiva en un entorno de trabajo. |
| C1 |
CT1 - Expresarse correctamente, tanto de forma oral coma escrita, en las lenguas oficiales de la comunidad autónoma |
| C4 |
CT4 - Desarrollarse para el ejercicio de una ciudadanía respetuosa con la cultura democrática, los derechos humanos y la perspectiva de género |
| C7 |
CT7 - Desarrollar la capacidad de trabajar en equipos interdisciplinares o transdisciplinares, para ofrecer propuestas que contribuyan a un desarrollo sostenible ambiental, económico, político y social. |
| C8 |
CT8 - Valorar la importancia que tiene la investigación, la innovación y el desarrollo tecnológico en el avance socioeconómico y cultural de la sociedad |
| C9 |
CT9 - Tener la capacidad de gestionar tiempos y recursos: desarrollar planes, priorizar actividades, identificar las críticas, establecer plazos y cumplirlos |
| Learning aims |
| Learning outcomes |
Study programme competences |
| To acquire knowledge and skills in the field of nanotechnology applied to the development of therapeutic nanosystems for the delivery and vectorization of drugs. |
A1
A2
A3
A10
|
B3
B4
B6
B7
B8
B9
B10
B11
B12
|
C1
C4
C7
C8
C9
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| To know the main biomaterials and current technologies used for the development of therapeutic nanosystems. |
A1
A5
A7
A10
|
B1
B2
B3
B5
B6
B7
B8
|
C1
C4
C7
C8
|
| To understand the main physiological barriers to the release of nanosystems and the main strategies to overcome these barriers. |
A1
A2
A10
|
B1
B2
B3
B5
B6
B7
B8
|
C1
C4
C7
C8
|
| To know the main therapeutic nanosystems used for the delivery of genes and proteins. |
A1
A2
A3
A10
|
B1
B2
B3
B5
B6
B7
B8
|
C1
C4
C7
C8
|
| Contents |
| Topic |
Sub-topic |
| Topic 1: Pharmaceutical nanotechnology. |
Introduction to Biopharmacy and relationship with Pharmaceutical Technology and Pharmacokinetics. |
| Topic 2: Basic aspects in Biopharmacy. |
-Conventional and modified pharmaceutical release forms.
-Profile absorption, distribution and elimination of drugs (ADME).
-Routes of administration of therapeutic nanosystems. |
| Topic 3: Drug delivery nanosystems: types, preparation methods and characterization. |
-Lipids, micelles, polymers, inorganic particles, carbon materials, etc.
-Methods of preparation, functionalization, characterization and encapsulation of drugs. |
| Topic 4: Mechanisms of internalization, intracellular trafficking and endosomal escape strategies of nanosystems. |
-Types of endocytosis of nanosystems.
-Effect of protein corona formation in nanosystems.
-Intracellular traffic and barriers to effective release.
-Endosomal escape strategies. |
| Topic 5: Vectorization of nanosystems: Passive and active strategies of selective orientation. |
-Passive vectoring strategies: Enhanced permeability and retention effect (EPR effect). Long circulating nanoparticles.
-Active vectoring strategies: Transport mediated by ligand-receptor interactions. Stimulus-sensitive nanoplatforms. |
| Topic 6: Protein and gene delivery nanosystems. |
-Protein expression and purification systems in the pharmaceutical industry.
-Formulation strategies for protein loads.
-Viral and non-viral gene therapy vectors; Nanovaccines, CAR-T therapy. |
| Topic 7: Ethical and legal aspects of nanosystems. |
Main biosafety considerations of therapeutic nanosystems. |
| Planning |
| Methodologies / tests |
Competencies |
Ordinary class hours |
Student’s personal work hours |
Total hours |
| Guest lecture / keynote speech |
A1 A2 A3 A10 B1 B2 B3 B4 B5 B6 B7 B8 B9 B11 B12 C1 C7 C8 C9 |
18 |
35.5 |
53.5 |
| Seminar |
A1 A2 A3 A5 A7 A10 B1 B2 B3 B6 B7 B8 B9 B10 B11 B12 C1 C4 C7 C8 C9 |
10 |
20 |
30 |
| Objective test |
A1 A2 A3 A5 A7 A10 B1 B2 B3 B6 B7 B8 B9 B11 B12 C1 C7 C8 C9 |
2 |
2 |
4 |
| Laboratory practice |
A1 A2 A3 A5 A7 A10 B6 B7 B8 B9 B10 B12 |
10 |
15 |
25 |
| |
| Personalized attention |
|
1 |
0 |
1 |
| |
| (*)The information in the planning table is for guidance only and does not take into account the heterogeneity of the students. |
| Methodologies |
|
Methodologies |
Description |
| Guest lecture / keynote speech |
The topics of the subject will be lectured by the teachers with the help of audiovisual media. The relevant documentation will be made available to students on the Virtual Campus. |
| Seminar |
Realization and exposition of a supervised work focused on the design of a therapeutic nanosystem and its application in the treatment of a human pathology. |
| Objective test |
Written test used to assess learning that can combine different types of questions including multiple-choice, association, explanatory, or problem-solving questions. |
| Laboratory practice |
A series of activities will be carried out in the practical laboratory related to the encapsulation of drugs in various therapeutic nanosystems. |
| Personalized attention |
|
Methodologies
|
| Seminar |
| Objective test |
| Laboratory practice |
|
| Description |
The quality of the work and its presentation in class will be evaluated.
Through an objective test, the knowledge acquired during the guest lectures will be evaluated.
The report and/or tasks that students have to deliver to the teacher will be evaluated. |
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| Assessment |
|
Methodologies
|
Competencies |
Description
|
Qualification
|
| Seminar |
A1 A2 A3 A5 A7 A10 B1 B2 B3 B6 B7 B8 B9 B10 B11 B12 C1 C4 C7 C8 C9 |
The quality of the work and its presentation in class will be evaluated. |
20 |
| Objective test |
A1 A2 A3 A5 A7 A10 B1 B2 B3 B6 B7 B8 B9 B11 B12 C1 C7 C8 C9 |
Through an objective test, the knowledge acquired during the expository classes will be evaluated. |
60 |
| Laboratory practice |
A1 A2 A3 A5 A7 A10 B6 B7 B8 B9 B10 B12 |
The report and/or tasks that students have to deliver to the teacher will be evaluated. |
20 |
| |
|
Assessment comments |
The final exam of the first call (at the end of the 2nd four-month-period) will represent 60% of the final grade and the remaining 40% will be made up of the practical memory and the exhibition of supervised work (20% and 20%, respectively). In order to apply the indicated percentages, the student must obtain a mark higher than 4 out of 10 in the exam. All those students who have participated in the Practices and delivered the evaluable work will be considered as presented students. The fraudulent performance of tests or evaluation activities, once verified, will directly imply the qualification of suspense in the call in which the offense is committed and with respect to the matter in which it was committed: the student will be graded as "failed" (numerical grade 0) in the corresponding call for the academic year, whether the infringement is carried out on the first opportunity or on the second. To do so, the qualification will be modified at the first opportunity, if necessary. |
| Sources of information |
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Basic
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-Nanotechnology in Drug Delivery. Editors : Melgardt M. Villiers, Pornanong Aramwit, Glen S. Kwon (2008). Publisher Springer. ISBN: 978-0-387-77668-2 DOI https://doi.org/10.1007/978-0-387-77667-5 - Nanobiotechnology in Diagnosis, Drug Delivery, and Treatment.Editors: Mahendra Rai, Mehdi Razzaghi-Abyaneh, Avinash P. Ingle (2021). John Wiley & Sons Ltd. India. ISBN:9781119671732|DOI:10.1002/9781119671732. -Physiological Pharmaceutics Barriers to Drug Absorption .Neena Washington;,Clive Washington;Clive Wilson. CRC press. ISBN 9780429204593 |
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Complementary
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- Nanoparticulate Materials: Synthesis, Characterization, and Processing. Kathy Lu (2012). John Wiley & Sons, Inc. Estados Undos. ISBN:9781118408995 |DOI:10.1002/9781118408995 - Tratado General de Biofarmacia y Farmacocinética, Domenech, J., Martínez, J. Peraire, C.Vol. 1 1ª Edición ISBN 9788499589527 - The Handbook of Nanomedicine. Kewal J Jain. Humana Press ISBN: 978-1-60327-318-3 |
| Recommendations |
| Subjects that it is recommended to have taken before |
| Techniques of Characterisation of Nanomaterials 2/610G04030 | | Techniques of Characterisation of Nanomaterials 1/610G04025 | | Fundamentals of Biotechnology/610G04029 | | Synthesis and Preparation of Nanomaterials/610G04020 | | Cell Biology/610G04003 |
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| Subjects that are recommended to be taken simultaneously |
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| Subjects that continue the syllabus |
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| Other comments |
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Recommendations Sustainability Environment, People and Gender Equality: To help achieve an immediate sustainable environment and meet the objective of action number 5: "Healthy and sustainable environmental and social teaching and research" of the "Green Campus Action Plan". 1.- The supervised works that are carried out in this subject will be submitted through Moodle, in digital format without the need to print them. 2.- The importance of ethical principles related to the values of sustainability in personal and professional behavior must be taken into account. 3. Full integration will be facilitated for students who, for physical, sensory, mental or sociocultural reasons, experience difficulties in achieving suitable, equal and beneficial access to university life. 4. Work will be done to identify and modify prejudices and sexist attitudes, and the environment will be influenced to modify them and promote values of respect and equality. Likewise, if adverse situations due to gender are identified, measures will be taken to correct them. 5. It is understood that university students must have assumed the linguistic capacities in relation to oral and written expression. Therefore, spelling, grammatical and lexical correction (spelling, accentuation and punctuation) will be essential and compulsorily in the works and exams carried out as an essential condition to pass the subject. In this subject, the general criteria of the UDC will be applied, in its
commitment to respect the gender perspective. |
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