| Study programme competencies |
| Code | Study programme competences |
| A8 | CE8 - Understanding the basis of the information of the hereditary material, its transmission, analysis and evolution |
| A9 | CE9 – To understand the benefits and the problems associated with the sequencing and the use of biological sequences, as well as knowing the structures and techniques for their processing |
| B1 | CB6 - Own and understand knowledge that can provide a base or opportunity to be original in the development and/or application of ideas, often in a context of research |
| B2 | CB7 - Students should know how to apply the acquired knowledge and ability to problem solving in new environments or little known within broad (or multidisciplinary) contexts related to their field of study |
| B5 | CB10 - Students should possess learning skills that allow them to continue studying in a way that will largely be self-directed or autonomous. |
| B6 | CG1 -Search for and select the useful information needed to solve complex problems, driving fluently bibliographical sources for the field |
| B7 | CG2 - Maintain and extend well-founded theoretical approaches to enable the introduction and exploitation of new and advanced technologies |
| B8 | CG3 - Be able to work in a team, especially of interdisciplinary nature |
| C1 | CT1 - Express oneself correctly, both orally writing, in the official languages of the autonomous community |
| C2 | CT2 - Dominate the expression and understanding of oral and written form of a foreign language |
| C3 | CT3 - Use the basic tools of the information technology and communications (ICT) necessary for the exercise of their profession and lifelong learning |
| C7 | CT7 – To maintain and establish strategies for scientific updating as a criterion for professional improvement. |
| C8 | CT8 - Rating the importance that has the research, innovation and technological development in the socio-economic and cultural progress of society |
| Learning aims | |||
| Learning outcomes | Study programme competences | ||
| Knowledge about the molecular tools used in genomics | AJ8 AJ9 |
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| Knowledge about structural, functional and evolutionary genomics | AJ8 |
BJ1 BJ2 |
CJ8 |
| To set up experiments and analyse and interpret data using DNA microarrays | BJ6 BJ7 |
CJ2 CJ3 |
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| Knowledge about the mechanisms involved in the evolution of genomes and the molecular and bioinformatic tools used in that kind of studies | BJ5 BJ8 |
CJ1 CJ7 |
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| Contents |
| Topic | Sub-topic |
| Introduction: from Molecular Genetics to Genomics | Molecular markers Applications ot recombinant DNA technologies PCR and real-time quantitative PCR Sanger sequencing DNA editing techniques |
| The Human Genome Project | Approaches for whole genome sequencing |
| Next Generation Sequencing (NGS) | Platforms Paired-end libraries Data files |
| Whole genome sequencing | Mate-pair libraries Annotation Comparative genomics Palaeogenomics |
| Metagenomics | Application |
| Clinical Genomics | Amplicon-seq Panel-seq Exome-seq Comparative genomic hybrisidation (CGH-array) Pharmacogenomics |
| Single Nucleotide Polymorphisms (SNPs) | Genome wide association studies (GWAS) Digital genetic testing |
| Functional Genomics | Transcriptome analysis: microarrays and NGS (RNA-seq, CHiP-seq) ENCODE project Epigenomics |
| Hands on | Introduction to the Integrative Genomics Viewer (IGV) Solving exercises using GALAXY and/or GENOMESPACE Gene expression analysis using BABELOMICS Pharmacogenomic analysis using PHARMGKB |
| Planning | ||||
| Methodologies / tests | Competencies | Ordinary class hours | Student’s personal work hours | Total hours |
| ICT practicals | B2 B5 B8 C3 | 21 | 42 | 63 |
| Mixed objective/subjective test | A8 A9 B2 C1 C2 C3 | 2 | 8 | 10 |
| Guest lecture / keynote speech | A8 A9 B1 B6 B7 C1 C2 C7 C8 | 21 | 52.5 | 73.5 |
| Personalized attention | 3.5 | 0 | 3.5 | |
| (*)The information in the planning table is for guidance only and does not take into account the heterogeneity of the students. | ||||
| Methodologies |
| Methodologies | Description |
| ICT practicals | Hands on: students solve exercises using their own laptop. |
| Mixed objective/subjective test | Assessment of the learning process. Tests may include multiple choice questions, problem solving and computer exercises. Instructors will decide whether scheduling a separate test for the computer exercises depending on the progress of the group. |
| Guest lecture / keynote speech | Each instructor will explain the basic contents of each topic interacting as much as possible with the students. |
| Personalized attention |
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| Assessment | |||
| Methodologies | Competencies | Description | Qualification |
| Guest lecture / keynote speech | A8 A9 B1 B6 B7 C1 C2 C7 C8 | Students must attend at least 80% of the lecturers in order to pass the subject. Scores will depend on the result of a multiple choice test. In addition, similar calculations to the ones worked during lectures may be required. |
70 |
| ICT practicals | B2 B5 B8 C3 | Students must attend at least 80% of the hands on sessions in order to pass the subject. Scores will depend on the result of an exam: students will use their own laptop to solve a set of exercises. This exam may be scheduled not to overlap with the "theory" test. |
30 |
| Assessment comments | |||
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In the event of having officially certified "part-time" students, the instructors will take the appropriate measures so that their scores are not affected. |
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| Sources of information |
| Basic |
Pevsner J (2015). Bioinformatics and Functional Genomics. Wiley Blackwell
Kulkarni S, Pfeifer J (2015). Clinical Genomics. A guide to Clinical NGS. Academic Press, Elsevier
Robison PN, Piro RM, Jäger M (2018). Computational Exome and Genome Analysis. CRC Press, Taylor & Francis Group
Campbell, AM & Heyer LJ (2007). Discovering Genomics, Proteomics & Bioinformatics. Pearson Benjamin Cummings
Brown TA (2018). Genomes4. Garland Science, Taylor & Francis Group |
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| Complementary | |
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| Recommendations | ||
| Subjects that it is recommended to have taken before | ||
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| Subjects that are recommended to be taken simultaneously |
| Subjects that continue the syllabus | |
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| Other comments | |
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Do not take this course unless your level of English is B1 or higher. |