Chapter 2. Pericyclic reactions |
Introduction: characteristics of pericyclic reactions and theoretical approaches. Electrocyclic, Cycloaddition reactions and sigmatropic rearrangements. |
Chapter 4. Generation of carbon-carbon bond by enols and enolates. |
Alkylation, acylation and conjugate addition of enols and enolates |
Chapter 6. Generation of carbon- heteroatom bonds |
Generation of carbon and oxygen, nitrogen, halide and sulfur bonds. Applications of organoboron chemistry to the generation of carbon-heteroatom bonds. |
Chapter 8. Protective groups in organic synthesis |
The role of protective groups in organic synthesis. The concept of orthogonal sets. Hydroxyl, diols, aldehyde and ketone carbonyl, carboxylic acid and amine protecting groups. |
Chapter 9. Retrosyntetic analysis. |
Synthetic analysis and planning. Retrosyntetic analysis methodology. Types of transformations: disconnections, connections, functional group interconversion, addition and removing functional groups. Economic issues in retrosyntetic analysis. Illustrative synthesis. s |