Teaching GuideTerm Faculty of Science |
Grao en Bioloxía |
Subjects |
Bioquímica e Bioloxía Molecular |
Contents |
|
|
|
Identifying Data | 2016/17 | |||||||||||||
Subject | Bioquímica e Bioloxía Molecular | Code | 610G02013 | |||||||||||
Study programme |
|
|||||||||||||
Descriptors | Cycle | Period | Year | Type | Credits | |||||||||
Graduate | 2nd four-month period |
Third | Obligatoria | 6 | ||||||||||
|
Topic | Sub-topic |
1.-Basal Transcription |
RNA polymerases, core promoter and general transcription factors.Transcription mechanism: initiation, elongation and termination. Methodology to study: transcription start site selection, transcriptional termination and interactions nucleic acids-proteins. |
2.-Regulated transcription and chromatin involvement in transcriptional regulation |
Activators and repressors. DNA binding domains: DNA-proteins interactions. Chromatin remodeling complexes. Acetilation, deacetilation and other histones modifications in the regulation of gene expression. Techniques to study transcriptional regulation. Regulation examples of specific genes |
3.-RNA processing and coordination of co-transcriptional events in eukaryotes |
RNA cleavage and polyadenylation. RNA splicing. Processing of ribosomic and transferent RNA |
4.-RNA as regulator of gene expression |
RNA edition. Control of mRNA quality. Function of snRNA and transcriptional regulation. sncRNAs and the gene silencing mechanism. Antisense RNA in the translational regulation and applications of RNA. RNomics aspects |
5.-Protein Translation |
General aspects. Ribosomes. Translation mechanism: Initiation, elongation and termination. Differences in eukaryotes. Translation in mitochondria. Translational inhibitors. |
6.-Protein Processing | Postranslational modifications of proteins. Folding: Chaperones and Prions. Ubiquitination and SUMOilation. Programed degradation: Proteasome |
7.-Protein Transport |
Cotranslational and postranslational translocation. Classification and distribution of new synthesized proteins. Traffic nucleo-cytoplasm. Transport regulation and final destiny of proteins in the cell. |
8.-Basics of Cell Signaling |
Classification of intercellular communication. Stages of intracellular signaling. Organization of signaling and pathways. Signaling molecules: types and functions. |
9.- Reception of external signals and intracellular transduction | Membrane and intracellular receptors: types and mechanisms of activation. Intercellular Messenger substances or Second Messengers, protein kinase cascades and signal transduction to nucleus. |
10.- Examples of control mechanisms and coordination of cell physiological activities | Cell Growth and Proliferation: regulation of cell cycle, apoptosis and cancer. Cell Senescence Signaling. |
|