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Teaching GuideTerm Faculty of Science |
| Grao en Nanociencia e Nanotecnoloxía |
 Subjects |
| Nanotechnology in Pharmacy |
| Contents |
| Identifying Data | 2023/24 | |||||||||||||
| Subject | Nanotechnology in Pharmacy | Code | 610G04043 | |||||||||||
| Study programme |
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| Descriptors | Cycle | Period | Year | Type | Credits | |||||||||
| Graduate | 2nd four-month period |
Fourth | Optional | 4.5 | ||||||||||
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| Topic | Sub-topic |
| Topic 1: Pharmaceutical nanotechnology. | Introduction to Biopharmacy and relationship with Pharmaceutical Technology and Pharmacokinetics. |
| Topic 2: Basic aspects in Biopharmacy. | -Conventional and modified pharmaceutical release forms. -Profile absorption, distribution and elimination of drugs (ADME). -Routes of administration of therapeutic nanosystems. |
| Topic 3: Drug delivery nanosystems: types, preparation methods and characterization. | -Lipids, micelles, polymers, inorganic particles, carbon materials, etc. -Methods of preparation, functionalization, characterization and encapsulation of drugs. |
| Topic 4: Mechanisms of internalization, intracellular trafficking and endosomal escape strategies of nanosystems. | -Types of endocytosis of nanosystems. -Effect of protein corona formation in nanosystems. -Intracellular traffic and barriers to effective release. -Endosomal escape strategies. |
| Topic 5: Vectorization of nanosystems: Passive and active strategies of selective orientation. | -Passive vectoring strategies: Enhanced permeability and retention effect (EPR effect). Long circulating nanoparticles. -Active vectoring strategies: Transport mediated by ligand-receptor interactions. Stimulus-sensitive nanoplatforms. |
| Topic 6: Protein and gene delivery nanosystems. | -Protein expression and purification systems in the pharmaceutical industry. -Formulation strategies for protein loads. -Viral and non-viral gene therapy vectors; Nanovaccines, CAR-T therapy. |
| Topic 7: Ethical and legal aspects of nanosystems. | Main biosafety considerations of therapeutic nanosystems. |
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