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Teaching GuideTerm Faculty of Science |
| Mestrado Universitario en Bioloxía Molecular , Celular e Xenética |
 Subjects |
| Regulation of gene expression |
| Contents |
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| Identifying Data | 2019/20 | |||||||||||||
| Subject | Regulation of gene expression | Code | 610441006 | |||||||||||
| Study programme |
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| Descriptors | Cycle | Period | Year | Type | Credits | |||||||||
| Official Master's Degree | 1st four-month period |
First | Obligatory | 3 | ||||||||||
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| Topic | Sub-topic |
| Topic 1 | Introduction to techniques and methodology to study the regulation of gene expression. |
| Topic 2 | The transcriptional machinery in eukaryotes. Transcripcional general factors (TFII) and TAFs. The mediator complex and the complex SRB10 kinase. |
| Topic 3 | The complexes that remodel chromatin. ATP-hydrolyzing complexes. SWI/SNF and ISWI complexes. |
| Topic 4 | SAGA complex and counterparts. Acetylation and regulation of gene expression: HATs. The gene repression processes and deacetylation. The repression mechanisms of gene methylation. |
| Topic 5 | Specific transcripcion factors. The signaling cascades and specific transcription factors. Nuclear receptors and transcriptional control. |
| Topic 6 | New concepts in the regulation of gene expression. Transcripcion factories and other models. |
| Topic 7 | RNA processing and nucleous-cytoplasm transport: the machinery of RNA cleavaje and polyadenylation, transport across the Nuclear Pore Complex and factors involved. Cytosolic polyadenylation. |
| Topic 8 | RNA secondary structures and protein-factors with RNA-binding domains in the regulation of mRNA levels. mRNA stability. |
| Topic 9 | RNA and protein translation. Local protein translation. The 3´-UTRs in the translation efficiency process. RNA Editing. |
| Topic 10 | micro and siRNAs in the regulation of Gene Expression: basic and applied aspects. |
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