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Teaching GuideTerm Faculty of Science |
| Grao en Química |
 Subjects |
| Advanced Organic Chemistry |
| Contents |
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| Identifying Data | 2023/24 | |||||||||||||
| Subject | Advanced Organic Chemistry | Code | 610G01030 | |||||||||||
| Study programme |
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| Descriptors | Cycle | Period | Year | Type | Credits | |||||||||
| Graduate | 1st four-month period |
Fourth | Obligatory | 6 | ||||||||||
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| Topic | Sub-topic |
| Chapter 1. Stereochemistry and conformational analysis | Static and dynamic stereochemistry. Stereoselective and stereospecific chemical reactions (chemo-, regio- and stereoselective/specific reactions). Conformational analysis: conformational effects on reactivity. |
| Chapter 2. Synthetic methods | Protective groups. Methodology of the retrosynthetic analysis. Types of transformations. Examples |
| Chapter 3. Pericyclic reactions | Introduction: characteristics of pericyclic reactions and theoretical approaches. Electrocyclic, Cycloaddition reactions and sigmatropic rearrangements. |
| Chapter 4. Generation of carbon-carbon bonds by Free-Radical reactions and carbenes. |
Structure. Radical preparation. Radical reactions: coupling, addition, fragmentation and rearrangements. Carbens. Diazomethane. Carbene reactions. Alkene metathesis |
| Chapter 5. Generation of carbon-carbon bond by enols and enolates. | Alkylation, acylation and conjugate addition of enols and enolates |
| Chapter 6. Generation of carbon-carbon double bond |
Wittig and Horner-Wadswoth-Emmons reactions. |
| Chapter 7. Generation of carbon-carbon bond and carbon –heteroatom bonds by organometallic compounds | Allylation of carbonyl compounds. Cross coupling reaction. Heck reaction. Carbon-heteroatom bond formation: Buchwald-Hartwig |
| Chapter 8. Functional group interconversion reactions mediated by reduction and oxidation transformations. | Functional group interconversion reactions through reduction and oxidation reactions. |
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