Teaching GuideTerm Faculty of Science |
Grao en Química |
Subjects |
Advanced Organic Chemistry |
Contents |
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Identifying Data | 2019/20 | |||||||||||||
Subject | Advanced Organic Chemistry | Code | 610G01030 | |||||||||||
Study programme |
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Descriptors | Cycle | Period | Year | Type | Credits | |||||||||
Graduate | 1st four-month period |
Fourth | Obligatory | 6 | ||||||||||
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Topic | Sub-topic |
Chapter 1. Stereochemistry and conformational analysis | Static and dynamic stereochemistry. Stereoselective and stereospecific chemical reactions (chemo-, regio- and stereoselective/specific reactions). Conformational analysis: conformational effects on reactivity. |
Chapter 2. Pericyclic reactions | Introduction: characteristics of pericyclic reactions and theoretical approaches. Electrocyclic, Cycloaddition reactions and sigmatropic rearrangements. |
Chapter 3. Free-Radical reactions | Generation and stability of free radicals. Main free-radical reactions. |
Chapter 4. Generation of carbon-carbon bond by enols and enolates. | Alkylation, acylation and conjugate addition of enols and enolates |
Chapter 5. Generation of carbon-carbon bond by organometallic compounds | Organometallic reagents to make carbon-carbon bonds. Reactions involving transition metal complexes. |
Chapter 6. Generation of carbon- heteroatom bonds | Generation of carbon and oxygen, nitrogen, halide and sulfur bonds. |
Chapter 7. Functional group interconversion reactions. | Main Functional group interconversion reactions Functional group interconversions through reduction and oxidation reactions. |
Chapter 8. Protective groups in organic synthesis | The role of protective groups in organic synthesis. The concept of orthogonal sets. Hydroxyl, diols, aldehyde and ketone carbonyl, carboxylic acid and amine protecting groups. |
Chapter 9. Retrosyntetic analysis. | Synthetic analysis and planning. Retrosyntetic analysis methodology. Types of transformations: disconnections, connections, functional group interconversion, addition and removing functional groups. Economic issues in retrosyntetic analysis. Illustrative synthesis. s |
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